INT228844

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.17
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ppp1r1b) nucleus (Ppp1r1b) intracellular (Ppp1r1b)
cytoplasm (Ppp1r1b)
Anatomy Link Frequency
output neurons 2
Ppp1r1b (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 117 99.20 Very High Very High Very High
Ventral tegmentum 25 96.96 Very High Very High Very High
dopamine receptor 14 75.44 Quite High
cocaine 15 75.12 Quite High
Nucleus accumbens 47 65.92 Quite High
antagonist 4 35.76 Quite Low
agonist 3 29.20 Quite Low
addiction 2 11.28 Low Low
Enkephalin 5 5.00 Very Low Very Low Very Low
substance P 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 99.88 Very High Very High Very High
Urological Neuroanatomy 2 73.68 Quite High
Attention Deficit Hyperactivity Disorder 10 5.00 Very Low Very Low Very Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Aggression 6 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Analysis of c-Fos, pTH, TH, and pDARPP-32 immunoreactivity
Regulation (immunoreactivity) of Gene_expression (Analysis) of pDARPP-32
1) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.03
The differences seen in c-Fos expression compared to pTH and pDARPP-32 expression also indicate that dopamine may not be the only player influencing neglect.
Regulation (seen) of Gene_expression (expression) of pDARPP-32 associated with dopamine
2) Confidence 0.32 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0.07 Pain Relevance 0.65
The generation of BAC transgenic mice expressing DARPP-32 with different tags under the control of drd1a and drd2 promoters allowed the analysis of DARPP-32 phosphorylation selectively in the two populations of striatal output neurons in vivo (Bateup et al., 2008) (Figure 1).
Regulation (under) of Gene_expression (expressing) of DARPP-32 in output neurons associated with targeted disruption
3) Confidence 0.09 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.10 Pain Relevance 0.09

General Comments

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