INT228850

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ppp1r1b) oxidoreductase activity (Dio1) endoplasmic reticulum (Dio1)
nucleus (Ppp1r1b) intracellular (Ppp1r1b) cytoplasm (Ppp1r1b)
Dio1 (Mus musculus)
Ppp1r1b (Mus musculus)
Pain Link Frequency Relevance Heat
dopamine receptor 6 99.04 Very High Very High Very High
Dopamine 48 95.56 Very High Very High Very High
Nucleus accumbens 19 25.28 Quite Low
Substantia nigra 1 14.36 Low Low
Ventral tegmentum 12 13.32 Low Low
cocaine 5 5.00 Very Low Very Low Very Low
Eae 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 5 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Aggression 3 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 2 5.00 Very Low Very Low Very Low
Anxiety Disorder 2 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 2 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Birth Weight 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of DARPP-32 is increased by D1-like, but not D2-like, dopamine receptors and is specifically phosphorylated on threonine34 (Thr34) in response to dopamine acting through a cAMP-dependent protein kinase (PKA) [53]–[55].
D1 Positive_regulation (increased) of Phosphorylation (Phosphorylation) of DARPP-32 associated with dopamine and dopamine receptor
1) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2276864 Disease Relevance 0 Pain Relevance 0.44

General Comments

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