INT228880

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Context Info
Confidence 0.24
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.26
Pain Relevance 2.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Akap12) protein targeting (Akap12) plasma membrane (Akap12)
cytoskeleton (Akap12) kinase activity (Akap12) cytoplasm (Akap12)
Anatomy Link Frequency
endothelial cells 1
neurons 1
dorsal horn 1
Akap12 (Mus musculus)
Pain Link Frequency Relevance Heat
c fibre 48 100.00 Very High Very High Very High
Dorsal horn 68 99.42 Very High Very High Very High
unmyelinated 64 99.00 Very High Very High Very High
nociceptor 8 94.08 High High
qutenza 224 88.48 High High
Sciatic nerve 8 82.64 Quite High
substantia gelatinosa 12 80.24 Quite High
Spinal cord 88 76.92 Quite High
dorsal root ganglion 44 34.24 Quite Low
superficial lamina 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 16 97.20 Very High Very High Very High
Ganglion Cysts 44 34.24 Quite Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 4 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, Meissner's corpuscles from glabrous skin appeared innervated by axons immunoreactive for both SSeCKS and CGRP suggesting that SSeCKS may be associated with neurons that convey light touch, in addition to those conveying nociceptive signals.
SSeCKS Binding (associated) of in neurons associated with nociception
1) Confidence 0.24 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.10 Pain Relevance 0.44
SSeCKS-IR was not found in association with any glial profiles but was found in endothelial cells as had been previously reported [12].
SSeCKS Neg (not) Binding (association) of in endothelial cells
2) Confidence 0.24 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0 Pain Relevance 0.32
At the ultrastructural level, the demonstration of SSeCKS labeling in bundled unmyelinated axons in dorsal horn outer laminae suggests that SSeCKS is associated with C-fibers central arborizations.
SSeCKS Binding (associated) of in dorsal horn associated with c fibre, dorsal horn and unmyelinated
3) Confidence 0.23 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.09 Pain Relevance 0.62
However, the presence of SSeCKS-IR in occasional thinly myelinated, small diameter axons indicates that SSeCKS is not exclusively contained in C-fibers and may also be associated with a small number of A-delta fibers.
SSeCKS Binding (associated) of associated with c fibre
4) Confidence 0.23 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.08 Pain Relevance 0.65

General Comments

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