INT228881

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.11
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Akap12) protein targeting (Akap12) plasma membrane (Akap12)
cytoskeleton (Akap12) kinase activity (Akap12) cytoplasm (Akap12)
Anatomy Link Frequency
dorsal 1
ganglia 1
dorsal horn 1
ventral 1
Akap12 (Mus musculus)
Pain Link Frequency Relevance Heat
superficial lamina 8 99.32 Very High Very High Very High
Dorsal horn 68 99.28 Very High Very High Very High
qutenza 224 99.02 Very High Very High Very High
Spinal cord 88 96.52 Very High Very High Very High
c fibre 48 91.76 High High
unmyelinated 64 63.36 Quite High
dorsal root ganglion 44 56.16 Quite High
Peripheral nervous system 8 36.32 Quite Low
Sciatic nerve 8 16.56 Low Low
substantia gelatinosa 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 44 56.16 Quite High
Nociception 16 16.00 Low Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 4 5.00 Very Low Very Low Very Low
Adhesions 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Preservation of a subpopulation of SSeCKS-IR somata in the sensory ganglia with a corresponding complete loss of SSeCKS-IR fibers in the dorsal horn following neonatal capsaicin exposure suggests that those somata ablated by capsaicin represent the ganglionic component of the intensely labeled axons terminating in the dorsal horn of the spinal cord.
Negative_regulation (loss) of SSeCKS in dorsal horn associated with qutenza, dorsal horn and spinal cord
1) Confidence 0.38 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0 Pain Relevance 1.05
In addition, a reduction in SSeCKS-IR was observed in the area dorsal and ventral to the central canal (lamina X) of the spinal cord (Fig. 4B inset).
Negative_regulation (reduction) of SSeCKS in dorsal associated with spinal cord
2) Confidence 0.28 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.06 Pain Relevance 0.57
Sections of sensory ganglia from capsaicin-treated animals revealed a considerable overall decrease in SSeCKS-IR.
Negative_regulation (decrease) of SSeCKS in ganglia associated with qutenza
3) Confidence 0.28 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0 Pain Relevance 0.44
In addition, a reduction in SSeCKS-IR was observed in the area dorsal and ventral to the central canal (lamina X) of the spinal cord (Fig. 4B inset).
Negative_regulation (reduction) of SSeCKS in ventral associated with spinal cord
4) Confidence 0.10 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.06 Pain Relevance 0.57

General Comments

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