INT228883

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.28
Pain Relevance 3.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Akap12) protein targeting (Akap12) plasma membrane (Akap12)
cytoskeleton (Akap12) kinase activity (Akap12) cytoplasm (Akap12)
Anatomy Link Frequency
dorsal 1
margins 1
ganglia 1
primary sensory neurons 1
dorsal horn 1
Akap12 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 336 100.00 Very High Very High Very High
Spinal cord 132 98.72 Very High Very High Very High
substance P 12 98.44 Very High Very High Very High
Dorsal horn 102 98.34 Very High Very High Very High
unmyelinated 96 97.80 Very High Very High Very High
calcitonin gene related peptide 6 97.60 Very High Very High Very High
Peripheral nervous system 12 96.64 Very High Very High Very High
c fibre 72 95.24 Very High Very High Very High
Calcitonin gene-related peptide 6 92.48 High High
Kinase C 6 91.92 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 66 90.96 High High
Adhesions 6 63.92 Quite High
Nociception 24 26.04 Quite Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low
Volume Depletion And Dehydration 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the dorsal horn of the spinal cord, double labeling for SSeCKS and acid phosphatase revealed that SSeCKS-IR fibers are localized to laminar levels dorsal to the dorsal-most third of lamina II outer.
Regulation (localized) of SSeCKS in dorsal associated with dorsal horn and spinal cord
1) Confidence 0.29 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.06 Pain Relevance 0.27
Preservation of a subpopulation of SSeCKS-IR somata in the sensory ganglia with a corresponding complete loss of SSeCKS-IR fibers in the dorsal horn following neonatal capsaicin exposure suggests that those somata ablated by capsaicin represent the ganglionic component of the intensely labeled axons terminating in the dorsal horn of the spinal cord.
Regulation (subpopulation) of SSeCKS in dorsal horn associated with qutenza, dorsal horn and spinal cord
2) Confidence 0.29 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0 Pain Relevance 1.08
It has been shown that approximately 40% of small primary sensory neurons contain SSeCKS-immunoreactivity in a population largely separate from substance P (95.2%), calcitonin gene related peptide (95.3%), or fluoride resistant acid phosphatase (55.0%) labeled cells.
Regulation (immunoreactivity) of SSeCKS in primary sensory neurons associated with calcitonin gene related peptide and substance p
3) Confidence 0.18 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Abstract Doc Link PMC2277419 Disease Relevance 0 Pain Relevance 0.31
A quantitative assessment of capsaicin effectiveness, using well-established methods, was essential prior to determining its effect on SSeCKS labeling.
Spec (determining) Regulation (effect) of SSeCKS associated with qutenza
4) Confidence 0.18 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0 Pain Relevance 0.47
The effect of neonatal capsaicin administration on SSeCKS-IR in adult animals was examined in both transverse spinal cord and sensory ganglia sections.
Spec (examined) Regulation (effect) of SSeCKS in ganglia associated with qutenza and spinal cord
5) Confidence 0.18 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.22 Pain Relevance 0.84
At the ultrastructural level, SSeCKS immunoreactivity was most commonly associated with axonal membrane margins of unmyelinated fibers.
Regulation (immunoreactivity) of SSeCKS in margins associated with unmyelinated
6) Confidence 0.18 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Abstract Doc Link PMC2277419 Disease Relevance 0 Pain Relevance 0.72

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