INT228884

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 22
Disease Relevance 1.72
Pain Relevance 10.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Akap12) protein targeting (Akap12) plasma membrane (Akap12)
cytoskeleton (Akap12) kinase activity (Akap12) cytoplasm (Akap12)
Anatomy Link Frequency
primary sensory neurons 4
plasma 2
spinal cord 2
neuronal 1
sciatic nerve 1
Akap12 (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 44 100.00 Very High Very High Very High
unmyelinated 352 99.84 Very High Very High Very High
qutenza 1232 99.46 Very High Very High Very High
Sciatic nerve 44 99.28 Very High Very High Very High
c fibre 264 98.98 Very High Very High Very High
substantia gelatinosa 66 98.92 Very High Very High Very High
fifth nerve 22 98.60 Very High Very High Very High
Spinal cord 484 97.28 Very High Very High Very High
Dorsal horn 374 96.40 Very High Very High Very High
Kinase C 22 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 88 94.88 High High
Ganglion Cysts 242 89.80 High High
Adhesions 22 83.36 Quite High
Volume Depletion And Dehydration 22 71.88 Quite High
Hypersensitivity 22 63.20 Quite High
Body Weight 22 54.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The subcellular localization of SSeCKS to the plasma membrane is consistent with that described for other AKAPS possessing a membrane-binding domain.
Localization (localization) of SSeCKS in plasma
1) Confidence 0.52 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.06 Pain Relevance 0.52
In glabrous skin, however, fluorescence and confocal microscopy revealed a colocalization of SSeCKS and Pzero in axons immediately proximal to peripheral nerve terminals.
Localization (colocalization) of SSeCKS in proximal
2) Confidence 0.52 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.07 Pain Relevance 0.44
In light of the findings reported here, we propose that SSeCKS-IR within the peripheral nervous system is localized within a subpopulation of neurochemically distinct C-fibers and occasional thinly myelinated A?
Localization (localized) of SSeCKS in peripheral nervous system associated with c fibre and peripheral nervous system
3) Confidence 0.52 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.22 Pain Relevance 0.81
We previously demonstrated [17] that SSeCKS-IR is predominantly localized within small, type B somata within sensory ganglia.
Localization (localized) of SSeCKS in ganglia
4) Confidence 0.52 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.09 Pain Relevance 0.92
This finding is in agreement with our failure to find co-localization between SSeCKS and Pzero in the sciatic nerve and dorsal root ganglia.
Localization (localization) of SSeCKS in sciatic nerve associated with sciatic nerve
5) Confidence 0.52 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.06 Pain Relevance 0.43
This may suggest that SSeCKS is localized in the distal-most terminations of myelinated fibers.
Localization (localized) of SSeCKS
6) Confidence 0.52 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.08 Pain Relevance 0.41
These results imply that SSeCKS may be localized within a neurochemically distinct subpopulation of C- or A?
Localization (localized) of SSeCKS
7) Confidence 0.52 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.06 Pain Relevance 0.25
Ultrastructural localization of SSeCKS
Localization (localization) of SSeCKS
8) Confidence 0.52 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0 Pain Relevance 0
The large, capsaicin-induced reduction (43%) in SSeCKS labeled cells confirms that SSeCKS is at least partially localized to the unmyelinated, or small myelinated capsaicin-sensitive primary sensory neuron population.
Localization (localized) of SSeCKS in primary sensory neuron associated with qutenza and unmyelinated
9) Confidence 0.49 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.08 Pain Relevance 0.89
These findings, along with the absence of SSeCKS-IR somata within the CNS, suggest that SSeCKS-IR axons seen in the spinal cord of control animals represent the central termination of C-fiber or A?
Neg (absence) Localization (absence) of SSeCKS in spinal cord associated with c fibre and spinal cord
10) Confidence 0.49 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.06 Pain Relevance 1.04
In conjunction with CNPase-IR displaying minimal colocalization with SSeCKS in laminae ventral to the substantia gelatinosa, this data showing regions of SSeCKS labeled myelinated fibers in C-fiber sparse areas suggests they are located in laminae outside the substantia gelatinosa, possibly in more ventral laminae.
Localization (colocalization) of SSeCKS in substantia gelatinosa associated with c fibre and substantia gelatinosa
11) Confidence 0.49 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.07 Pain Relevance 0.57
In the dorsal root ganglia, SSeCKS-IR was localized within the cytoplasm of a specific subpopulation of small diameter neuronal perikarya.
Localization (localized) of SSeCKS in neuronal
12) Confidence 0.49 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.08 Pain Relevance 0.25
At the subcellular level, SSeCKS-IR was consistently localized to the plasma membrane and was frequently observed as a granular deposition throughout axonal cytoplasm (Fig. 2C, enlargement).
Localization (localized) of SSeCKS in plasma
13) Confidence 0.49 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0 Pain Relevance 0.23
These results demonstrate that SSeCKS is primarily localized within a distinct subpopulation of small diameter, largely unmyelinated C-fiber primary sensory neurons putatively involved in nociception.



Localization (localized) of SSeCKS in primary sensory neurons associated with nociception, c fibre and unmyelinated
14) Confidence 0.46 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Abstract Doc Link PMC2277419 Disease Relevance 0.09 Pain Relevance 0.72
Evaluation of colocalization between SSeCKS and CNPase at both the fluorescence and confocal microscope level suggests myelinated axons in the dorsal horn of the spinal cord contain minimal SSeCKS-IR.
Localization (colocalization) of SSeCKS in spinal cord associated with dorsal horn and spinal cord
15) Confidence 0.46 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0 Pain Relevance 0.46
However, in glabrous skin from the hindpaw, colocalization of Pzero and SSeCKS was observed toward peripheral axon terminals (Fig. 1D) and in the immediate vicinity of Meissner's corpuscles (not shown).
Localization (colocalization) of SSeCKS in corpuscles
16) Confidence 0.46 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.08 Pain Relevance 0.15
Given that our previous study raised the possibility, but did not demonstrate, that SSeCKS primary sensory neurons are largely unmyelinated C-fibers, the neonatal capsaicin model and ultrastructural localization of SSeCKS is employed here to further investigate and clarify the functional and morphological identification of SSeCKS-IR neurons.
Localization (localization) of SSeCKS in primary sensory neurons associated with c fibre, qutenza and unmyelinated
17) Confidence 0.46 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.19 Pain Relevance 0.98
Localization of SSeCKS in unmyelinated primary sensory neurons

Background

Localization (Localization) of SSeCKS in primary sensory neurons associated with unmyelinated
18) Confidence 0.46 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Title Doc Link PMC2277419 Disease Relevance 0 Pain Relevance 0.30
In peripheral nerve, colocalization of SSeCKS-labeled fibers and those associated with Pzero immunoreactivity (Fig. 1C) could not be established.
Localization (colocalization) of SSeCKS in peripheral nerve
19) Confidence 0.46 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.09 Pain Relevance 0.15
Relationship of SSeCKS with markers of myelination
Localization (Relationship) of SSeCKS
20) Confidence 0.42 Published 2008 Journal J Brachial Plex Peripher Nerve Inj Section Body Doc Link PMC2277419 Disease Relevance 0.15 Pain Relevance 0.46

General Comments

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