INT228893

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.81
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TFRC) peptidase activity (TFRC) mitochondrion (TFRC)
aging (TFRC) extracellular region (TFRC) cytoplasmic membrane-bounded vesicle (TFRC)
Anatomy Link Frequency
CHr 1
TFRC (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1 53.08 Quite High
spinal inflammation 1 46.88 Quite Low
palliative 2 5.04 Very Low Very Low Very Low
headache 8 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
backache 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
visual analogue scale 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaemia 104 99.92 Very High Very High Very High
Cancer 68 99.78 Very High Very High Very High
Iron Overload 8 94.56 High High
Fever 69 85.92 High High
Disease 27 83.48 Quite High
Infection 8 75.12 Quite High
Sprains And Strains 10 68.12 Quite High
Arenavirus Infection 8 67.80 Quite High
Flavivirus Infection 4 62.80 Quite High
Diabetes Mellitus 1 60.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Even assuming this to be true, the diversity of the GP1 amino acid sequences of Junín, Machupo, Guanarito, Sabiá and Chapare viruses is such that one cannot easily discern the GP1 domain involved in high efficiency binding to TfR1 solely on the basis of amino acid sequence alignments.
TfR1 Binding (binding) of
1) Confidence 0.16 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2277458 Disease Relevance 0.63 Pain Relevance 0
In cancer anemia, a combination of % HYPO, TfR, and CHr have been used to create a diagnostic plot which effectively identifies FID (Thomas et al 2006).
TfR Binding (combination) of in CHr associated with anaemia and cancer
2) Confidence 0.13 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504072 Disease Relevance 0.75 Pain Relevance 0
Presumably, Chapare virus will be found to have similar TfR1 binding properties, but this remains to be confirmed.
TfR1 Binding (binding) of
3) Confidence 0.11 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2277458 Disease Relevance 0.50 Pain Relevance 0
2 domains interact with the transferrin receptor and regulate iron uptake.
transferrin receptor Binding (interact) of
4) Confidence 0.02 Published 2007 Journal Yonsei Medical Journal Section Body Doc Link PMC2628004 Disease Relevance 0.93 Pain Relevance 0.03

General Comments

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