INT228900

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.60
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (RPS6KB1) aging (RPS6KB1) ribosome (RPS6KB1)
cytoplasm (RPS6KB1) cytosol (RPS6KB1) signal transduction (RPS6KB1)
Anatomy Link Frequency
uterine 2
RPS6KB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
backache 1 15.72 Low Low
Pain 4 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Chronic pancreatitis 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Antiemetics 1 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 89 98.80 Very High Very High Very High
Pancreatic Cancer 36 95.94 Very High Very High Very High
Metastasis 10 88.40 High High
Colorectal Cancer 4 80.40 Quite High
Leiomyosarcoma 18 76.44 Quite High
Epithelioid Leiomyoma 4 75.12 Quite High
Smooth Muscle Tumor 14 67.44 Quite High
Disease 25 65.08 Quite High
Uterine Fibroids 7 61.68 Quite High
Uterine Cancer 3 59.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The recent demonstration of elevated phospho-p70S6K and reduced phospho-AKT expression, indicative of mTOR (mammalian target of rapamycin) activation, in a group of extra-renal PEComas raises the possibility of using mTOR inhibitors such as rapamycin in the treatment of uterine PEComas and is another argument for their routine segregation [82].
Positive_regulation (elevated) of Gene_expression (expression) of p70S6K in uterine
1) Confidence 0.49 Published 2008 Journal Int Semin Surg Oncol Section Body Doc Link PMC2278149 Disease Relevance 0.84 Pain Relevance 0
The phosphoinositide 3-OH kinase (PI3K)/Akt pathway, which is frequently amplified or activated in pancreatic cancer, may also contribute to resistance in several ways including the inhibition of proapoptotic proteins BAD and caspase 9 (Schlieman et al. 2003), dysregulation of the mammalian target of rapamycin (mTOR)-S6K1 signaling pathway (Asano et al. 2005), and activation of the nuclear factor kappa B (NF?
Positive_regulation (activation) of Gene_expression (signaling) of S6K1 associated with pancreatic cancer
2) Confidence 0.34 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012429 Disease Relevance 0.76 Pain Relevance 0

General Comments

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