INT228901

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.44
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (RPS6KB1) aging (RPS6KB1) ribosome (RPS6KB1)
cytoplasm (RPS6KB1) cytosol (RPS6KB1) signal transduction (RPS6KB1)
Anatomy Link Frequency
uterine 1
RPS6KB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 8 83.84 Quite High
rheumatoid arthritis 1 71.60 Quite High
Bile 1 63.28 Quite High
tolerance 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
lidocaine 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
antidepressant 1 5.00 Very Low Very Low Very Low
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 110 98.80 Very High Very High Very High
Shock 1 96.86 Very High Very High Very High
Metastasis 16 88.40 High High
INFLAMMATION 7 83.84 Quite High
Osteoporotic Fractures 1 78.40 Quite High
Leiomyosarcoma 18 76.44 Quite High
Systemic Sclerosis 1 75.36 Quite High
Epithelioid Leiomyoma 4 75.12 Quite High
Carcinoma 9 74.16 Quite High
Renal Cell Carcinoma 58 73.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Activation of S6K1 itself is also tightly regulated by hierarchical phosphorylation events, which are dependent on the activation of various signal transduction pathways and culminate in the phosphorylation of the rapamycin-sensitive site Thr389.32,33 Hence, reductions in S6 phosphorylation by everolimus is expected to parallel S6K1 inactivation.
Positive_regulation (Activation) of S6K1
1) Confidence 0.55 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.12 Pain Relevance 0
The recent demonstration of elevated phospho-p70S6K and reduced phospho-AKT expression, indicative of mTOR (mammalian target of rapamycin) activation, in a group of extra-renal PEComas raises the possibility of using mTOR inhibitors such as rapamycin in the treatment of uterine PEComas and is another argument for their routine segregation [82].
Positive_regulation (elevated) of p70S6K in uterine
2) Confidence 0.45 Published 2008 Journal Int Semin Surg Oncol Section Body Doc Link PMC2278149 Disease Relevance 0.84 Pain Relevance 0
This includes an increase of eNOS activity via heat-shock protein 90 (HSP 90), which increases nitric oxide production, protein synthesis and cell proliferation via mammalian target of rapamycin (mTOR) pathway and activation of S6K.
Positive_regulation (activation) of S6K associated with shock
3) Confidence 0.43 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686255 Disease Relevance 0.80 Pain Relevance 0.18
-untranslated regions and encoding proteins involved in G1- to S-phase progression.30 Mitogen-induced activation of the S6K1 is dependent on mTOR function and has been implicated in the translational regulation of mRNAs possessing a 5?
Positive_regulation (activation) of S6K1
4) Confidence 0.40 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.15 Pain Relevance 0
The insulin activation of mTOR and S6K1 kinase works through the IRS-1/PI 3-kinase/Akt pathway, while amino acids seem to exert a direct effect on mTOR [41,42].
Positive_regulation (activation) of S6K1
5) Confidence 0.23 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.30 Pain Relevance 0
Activation of mTOR and S6K1 kinase leads to serine phosphorylation of IRS-1, with a subsequent decline in tyrosine phosphorylation of IRS-1 and IRS-1-associated PI 3-kinase activity, as discussed above.
Positive_regulation (Activation) of S6K1
6) Confidence 0.23 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2761378 Disease Relevance 0.24 Pain Relevance 0

General Comments

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