INT22891

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Context Info
Confidence 0.69
First Reported 1989
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 11.52
Pain Relevance 3.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)
Anatomy Link Frequency
neutrophils 10
liver 4
chondrocytes 2
adrenal glands 2
blood 2
ELANE (Homo sapiens)
Pain Link Frequency Relevance Heat
Angina 22 99.84 Very High Very High Very High
Inflammation 123 99.76 Very High Very High Very High
Nicotine 87 99.62 Very High Very High Very High
anesthesia 19 98.80 Very High Very High Very High
cytokine 41 98.08 Very High Very High Very High
qutenza 7 95.76 Very High Very High Very High
agonist 5 91.24 High High
metalloproteinase 39 91.08 High High
Clonidine 49 90.50 High High
antidepressant 1 89.66 High High
Disease Link Frequency Relevance Heat
Pyelonephritis 4 100.00 Very High Very High Very High
Colitis 10 99.88 Very High Very High Very High
Cv General 3 Under Development 21 99.84 Very High Very High Very High
INFLAMMATION 152 99.76 Very High Very High Very High
Stress 134 99.76 Very High Very High Very High
Coagulation Disorder 18 99.12 Very High Very High Very High
Urological Neuroanatomy 10 98.72 Very High Very High Very High
Myocardial Infarction 21 98.68 Very High Very High Very High
Acute Coronary Syndrome 35 98.04 Very High Very High Very High
Cirrhosis 71 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The secretion of elastase from neutrophils into BALF was stimulated during the course of general anesthesia.
Positive_regulation (stimulated) of Localization (secretion) of elastase in neutrophils associated with anesthesia
1) Confidence 0.69 Published 2006 Journal Transl Res Section Abstract Doc Link 16890150 Disease Relevance 0.22 Pain Relevance 0.45
In assessing the elevated NE epilepsy hypothesis, the following seven lines of evidence are examined that include studies of: (1) antidepressants that raise the level of NE; (2) clonidine and other alpha 2 adrenergic agonist drugs that lower the level of NE; (3) prazosin and other drugs that affect alpha adrenoceptors; (4) propranolol and other drugs that affect beta adrenoceptors; (5) pheochromocytoma, which is a rare cancer of the adrenal glands that can boost NE levels; (6) comorbidity of epilepsy with bipolar disorder, hypertension, and obesity, where all four conditions may involve elevated NE; and (7) psychological stress, which is associated with increased release of NE.
Positive_regulation (increased) of Localization (release) of NE in adrenal glands associated with stress, adrenal cancer, pheochromocytoma, clonidine, epilepsy, antidepressant, manic depressive disorder, obesity, agonist and hypertension
2) Confidence 0.61 Published 2010 Journal Seizure Section Abstract Doc Link 20493725 Disease Relevance 0.91 Pain Relevance 0.28
Increased neutrophil elastase release in unstable angina pectoris and acute myocardial infarction.
Positive_regulation (Increased) of Localization (release) of neutrophil elastase in neutrophil associated with angina and myocardial infarction
3) Confidence 0.47 Published 1990 Journal J. Am. Coll. Cardiol. Section Title Doc Link 2345235 Disease Relevance 1.12 Pain Relevance 0.63
To test our hypothesis that extracellular elastase release during acute pyelonephritis may contribute to subsequent renal parenchymal damage, we compared the intracellular and extracellular activities of the lysozyme elastase of human polymorphonuclear cells (PMN) when incubated in vitro with bacterial strains causing renal infection that led to either renal damage or no damage.
Spec (may) Positive_regulation (contribute) of Localization (release) of elastase associated with sprains and strains, pyelonephritis and infection
4) Confidence 0.44 Published 1995 Journal Pediatr. Nephrol. Section Abstract Doc Link 8580015 Disease Relevance 0.92 Pain Relevance 0.12
Specifically, by increasing the responsivity of cortical representations after cue presentation, LC-induced phasic NE release can enhance the effects of target selection by location (e.g., the top-down modulation by prefrontal cortex), resulting in an increased validity effect.
Positive_regulation (enhance) of Localization (release) of NE in cortex
5) Confidence 0.35 Published 2007 Journal Psychopharmacology (Berl) Section Body Doc Link PMC1915624 Disease Relevance 0 Pain Relevance 0.47
In vitro, the fungal enzyme preparation stimulated elastase release from isolated neutrophils and eliminated plasmatic inhibitors and plasminogen in normal plasma and whole blood.
Positive_regulation (stimulated) of Localization (release) of elastase in blood
6) Confidence 0.34 Published 1989 Journal Toxicology Section Abstract Doc Link 2469140 Disease Relevance 0.78 Pain Relevance 0.09
Ulinastatin attenuates the elevation of neutrophil elastase release, thereby blunting the rise of pro-inflammatory cytokine levels; however, the actual mechanism in vivo is not clear [6,7].
Positive_regulation (elevation) of Localization (release) of neutrophil elastase in neutrophil associated with inflammation and cytokine
7) Confidence 0.28 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.68 Pain Relevance 0.28
Elastase releasing capacity was estimated by the fMLP-induced elastase release from separated neutrophils in vitro and expressed as % increase of released elastase activity induced by 0.2 microM fMLP.
Positive_regulation (increase) of Localization (released) of elastase in neutrophils
8) Confidence 0.21 Published 1997 Journal Masui Section Abstract Doc Link 9028081 Disease Relevance 0.17 Pain Relevance 0.09
1 production could be involved in HNE-induced 5-LOX and FLAP expression, chondrocytes were treated or not with a single addition of 10 ?
Positive_regulation (involved) of Neg (not) Localization (treated) of HNE-induced in chondrocytes
9) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.05 Pain Relevance 0.03
HNE-induced LTB4 release through 5-LOX and FLAP upregulation
Positive_regulation (upregulation) of Localization (release) of HNE-induced
10) Confidence 0.18 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875653 Disease Relevance 0.20 Pain Relevance 0.10
Our hypothesis that HNE modification of Hsp70 or Hsp90 leads to the release and activation of HSF1 is supported by a reasonable body of in vitro and in vivo results.19,27–29,40,41 However, it is also possible that modification of other cellular proteins leads to their unfolding, which attracts Hsp90 away from HSF1.
Positive_regulation (leads) of Localization (modification) of HNE in body
11) Confidence 0.16 Published 2010 Journal Accounts of Chemical Research Section Body Doc Link PMC2873822 Disease Relevance 0.53 Pain Relevance 0
Elastase and leukotriene B4 release were also significantly increased in active colitis compared with inactive colitis and controls.
Positive_regulation (increased) of Localization (release) of Elastase associated with colitis
12) Confidence 0.14 Published 1995 Journal Clin. Sci. Section Abstract Doc Link 8549067 Disease Relevance 1.31 Pain Relevance 0.06
We conclude that NPC 15669 is an effective inhibitor of antigen-induced leukocyte recruitment and elastase release and subsequent hypersecretion in airways.
Positive_regulation (antigen-induced) of Localization (release) of elastase in leukocyte
13) Confidence 0.07 Published 1994 Journal Am. J. Physiol. Section Abstract Doc Link 7943251 Disease Relevance 0.31 Pain Relevance 0.10
The peritoneal macrophages from rats fed cod-liver oil diet secreted lower levels of lysosomal enzymes collagenase, elastase and hyaluronidase as compared to those from rats fed coconut oil or groundnut oil diets.
Positive_regulation (levels) of Localization (secreted) of elastase in liver
14) Confidence 0.07 Published 2000 Journal Mol. Cell. Biochem. Section Abstract Doc Link 10724344 Disease Relevance 0 Pain Relevance 0.32
Finally, oxidative stress as well as increased generation of ROS, HNE, NO and RNS have been unequivocally detected in all clinical conditions and animal models of fibrogenic CLD; moreover, administration of antioxidant agents in animal models usually offers prevention ([35,36] and references therein).


Positive_regulation (increased) of Localization (generation) of HNE associated with stress
15) Confidence 0.06 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.62 Pain Relevance 0.11
It has recently recognized that polymorphonuclear neutrophils (PMNs) are critical mediators in ACS, because of their recruitment and activation before platelet aggregation.46 One of the principal mediators secreted on PMN activation is myeloperoxidase (MPO), a hemoproteine that is a microbicidal enzyme, but it has also potent proatherogenic properties: infact, MPO can oxidize LDL cholesterol, amplificating uptake by macrophages and perpetuating foam cell formation.47 Moreover, MPO promotes activation of metalloproteinases and destabilization and rupture of atherosclerotic plaques surface.48 Furthermore, MPO catalytically consumes endothelium-derived nitric oxide, reducing its bioavailability and impairing its vasodilatory and anti-inflammatory functions.49
Positive_regulation (mediators) of Localization (secreted) of PMN in plaques associated with atherosclerotic plaque, acute coronary syndrome, inflammation, rupture, metalloproteinase, urological neuroanatomy and bioavailability
16) Confidence 0.04 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2716777 Disease Relevance 1.69 Pain Relevance 0.22
We conclude that the presence of HLE contributes significantly to the coagulopathy of patients with ALF, and this is not seen in patients with stable liver cirrhosis.
Positive_regulation (contributes) of Localization (presence) of HLE in liver associated with coagulation disorder, cirrhosis and acute liver failure
17) Confidence 0.03 Published 2009 Journal Liver International Section Body Doc Link PMC2711256 Disease Relevance 1.16 Pain Relevance 0
Importantly, nicotine has been shown to induce the release of elastase from human neutrophils [25], which may play a major role in tobacco-induced destructive diseases, such as COPD.
Positive_regulation (induce) of Localization (release) of elastase in neutrophils associated with nicotine, chronic obstructive pulmonary disease and disease
18) Confidence 0.01 Published 2008 Journal BMC Cell Biol Section Body Doc Link PMC2375863 Disease Relevance 0.87 Pain Relevance 0.09

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