INT22898

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.52
Pain Relevance 3.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Gls)
Anatomy Link Frequency
spinal 1
primary sensory neurons 1
dorsal horn 1
Gls (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opiate 4 100.00 Very High Very High Very High
Inflammation 21 99.78 Very High Very High Very High
Analgesic 3 99.78 Very High Very High Very High
Glutamate 15 99.66 Very High Very High Very High
Physical dependence 1 99.32 Very High Very High Very High
analgesia 6 97.56 Very High Very High Very High
Dorsal horn 3 97.48 Very High Very High Very High
excitatory amino acid 3 95.00 High High
ketamine 2 92.48 High High
Glutamate receptor 3 91.52 High High
Disease Link Frequency Relevance Heat
Drug Dependence 1 99.32 Very High Very High Very High
INFLAMMATION 15 98.24 Very High Very High Very High
Pressure And Volume Under Development 6 85.20 High High
Syndrome 4 75.00 Quite High
Inflammatory Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Peripheral inhibition of glutaminase reduces carrageenan-induced Fos expression in the superficial dorsal horn of the rat.
Negative_regulation (inhibition) of glutaminase in dorsal horn associated with analgesic and dorsal horn
1) Confidence 0.45 Published 2010 Journal Neurosci. Lett. Section Title Doc Link 20132864 Disease Relevance 0.36 Pain Relevance 0.89
The development of physical dependence on opiates appears to involve an inhibition by opiates of L-asparaginase and glutaminase, and the blockade by opiates of aspartatergic (ASPergic)/glutamatergic (GLUergic) receptors.
Negative_regulation (inhibition) of glutaminase associated with physical dependence and opiate
2) Confidence 0.40 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2345761 Disease Relevance 0.24 Pain Relevance 0.84
In this study, we measured the effects of glutaminase inhibition on carrageenan-induced spinal Fos expression.
Negative_regulation (inhibition) of glutaminase in spinal
3) Confidence 0.33 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20132864 Disease Relevance 0.49 Pain Relevance 0.72
The enzyme glutaminase is used by primary sensory neurons to convert glutamine to glutamate, and peripheral inhibition of glutaminase with 6-diazo-5-oxo-l-norleucine (DON) provides long-lasting analgesia during inflammation.
Negative_regulation (inhibition) of glutaminase in primary sensory neurons associated with glutamate, inflammation and analgesia
4) Confidence 0.29 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20132864 Disease Relevance 0.42 Pain Relevance 0.74

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox