INT22900

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Context Info
Confidence 0.67
First Reported 1990
Last Reported 2011
Negated 3
Speculated 2
Reported most in Body
Documents 126
Total Number 128
Disease Relevance 82.77
Pain Relevance 16.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Cd4) plasma membrane (Cd4) enzyme binding (Cd4)
Anatomy Link Frequency
T cells 64
lung 5
regulatory T cells 4
lymphocytes 3
B cells 3
Cd4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1303 100.00 Very High Very High Very High
Arthritis 89 99.92 Very High Very High Very High
allodynia 5 99.90 Very High Very High Very High
Demyelination 10 99.88 Very High Very High Very High
cytokine 1110 99.82 Very High Very High Very High
qutenza 20 99.82 Very High Very High Very High
cINOD 36 99.80 Very High Very High Very High
rheumatoid arthritis 406 99.48 Very High Very High Very High
Pain 83 99.38 Very High Very High Very High
fibrosis 140 99.18 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1426 100.00 Very High Very High Very High
Influenza Virus Infection 533 100.00 Very High Very High Very High
Apoptosis 372 100.00 Very High Very High Very High
Targeted Disruption 345 100.00 Very High Very High Very High
Chlamydia Infection 278 100.00 Very High Very High Very High
Death 214 100.00 Very High Very High Very High
Malignant Neoplastic Disease 61 100.00 Very High Very High Very High
Infection 1445 99.92 Very High Very High Very High
Experimental Arthritis 13 99.92 Very High Very High Very High
Contact Dermatitis 7 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data suggest that the enhanced production of IL-2 in mice given pain stimulation resulted from the activation of L3T4- T cells by endogenous catecholamines released from the adrenal gland after pain stimulation.
Positive_regulation (activation) of L3T4 in adrenal gland associated with pain and catecholamine
1) Confidence 0.67 Published 1994 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 7825812 Disease Relevance 0.70 Pain Relevance 0.78
Skin application of ketoprofen systemically suppresses contact hypersensitivity by inducing CD4(+) CD25(+) regulatory T cells.
Positive_regulation (inducing) of CD4 in regulatory T cells associated with contact dermatitis
2) Confidence 0.64 Published 2009 Journal J. Dermatol. Sci. Section Title Doc Link 19157794 Disease Relevance 0.20 Pain Relevance 0.10
Here we found that the number of TRAP-positive osteoclasts was significantly increased in CD4+CD25?
Positive_regulation (increased) of CD4 in osteoclasts
3) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2440798 Disease Relevance 0.41 Pain Relevance 0.13
HCT1026 treatment was associated to (i) decreased mRNA levels of pro-inflammatory cytokines, caspase-1, and iNOS in blood cells; (ii) decreased ability of encephalitogenic T cells to proliferate; (iii) reduced number of central nervous system (CNS)-infiltrating T cells; (iv) decreased axonal loss and demyelination; (v) increased CD4(+) CD69(-) CD25(+) regulatory T cells in the spleen.
Positive_regulation (increased) of CD4 in central nervous system associated with demyelination, inflammation, central nervous system and cytokine
4) Confidence 0.58 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 15081244 Disease Relevance 0.82 Pain Relevance 0.37
This specific induction of CD4 T cells was significantly higher compared to the MVA wild-type group (P<0.05).
Positive_regulation (induction) of CD4 in T cells
5) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.35 Pain Relevance 0.04
To analyze whether the live vaccines, besides inducing high levels of influenza-specific CD4 and CD8 T-cells in the spleen shortly after booster immunization, also give rise to significant levels of HA-specific T-cells at the site of influenza infection, influenza-specific interferon ?
Spec (whether) Positive_regulation (inducing) of CD4 in T-cells associated with influenza virus infection and immunization
6) Confidence 0.55 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2922371 Disease Relevance 0.39 Pain Relevance 0
The fact that effector CD4 and CD8 T cells are required for the clearance of RNA virus infections, the increased percentages of activated CD4 and CD8 T cells likely plays a imperative role in clearing influenza viruses from the lung despite altering the inflammatory cells recruited to the lung.
Positive_regulation (activated) of CD4 in lung associated with inflammation, influenza virus infection and infection
7) Confidence 0.51 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2953496 Disease Relevance 1.14 Pain Relevance 0.20
Sevoflurane diminished the number of peripheral blood lymphocytes and splenic B-cell counts, enhancing CD4+ lymphocytes in spleen.
Positive_regulation (enhancing) of CD4 in blood
8) Confidence 0.50 Published 2002 Journal Int. Immunopharmacol. Section Abstract Doc Link 11789673 Disease Relevance 0 Pain Relevance 0.39
Flow cytometry was subsequently used to enumerate the percentages of emanating CD4+ and CD8+ T cells.
Positive_regulation (emanating) of CD4 in T cells
9) Confidence 0.48 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2605729 Disease Relevance 0 Pain Relevance 0
No differences in the activation of peripheral CD4(+) T lymphocytes were detected in either the spleen or lumbar lymph nodes between L5Tx and sham surgery groups.
Positive_regulation (activation) of CD4 in lumbar lymph nodes
10) Confidence 0.46 Published 2008 Journal Eur. J. Immunol. Section Abstract Doc Link 18196515 Disease Relevance 0.40 Pain Relevance 0.39
Significantly fewer CD4+ IFN-?
Positive_regulation (fewer) of CD4
11) Confidence 0.46 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 0.64 Pain Relevance 0.07
Treatment with pBTLA reduces CD4+ T cell response to HSV-1 infection in corneas
Positive_regulation (response) of CD4 in corneas associated with cold sores and infection
12) Confidence 0.46 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 1.15 Pain Relevance 0.14
RENCA tumors in RENCA-H6- vaccinated animals contained large populations of NK cells and activated CD4+, CD8+ T cells.
Positive_regulation (activated) of CD4 in T cells associated with cancer
13) Confidence 0.46 Published 2010 Journal Cancer Gene Ther. Section Abstract Doc Link 20168352 Disease Relevance 0.53 Pain Relevance 0.23
The efficient induction of CD25 +CD4 + reguratory T cells is expected for the new type of treatment of AD.
Positive_regulation (induction) of CD4 in T cells associated with eczema
14) Confidence 0.45 Published 2010 Journal Allergy, Asthma & Immunology Research Section Abstract Doc Link PMC2946701 Disease Relevance 0.61 Pain Relevance 0.08
Conversely, both of the less acute bacterial infection patient groups showed normal CD8+ T activation, but an increased level in the CD4+ T cells, with significance for the Tb (tuberculosis) group at p < 0.02.
Positive_regulation (increased) of CD4 in T cells associated with mycobacterial infection and bacterial infection
15) Confidence 0.43 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC2912311 Disease Relevance 1.28 Pain Relevance 0
The isotype control for both cytokines is also shown for the CD4+CD25+ population. b Upon adoptive transfer of CD4+CD25+ cells from protected mice, some (n?
Positive_regulation (shown) of CD4 associated with cytokine
16) Confidence 0.43 Published 2010 Journal Diabetologia Section Body Doc Link PMC2910887 Disease Relevance 0.21 Pain Relevance 0.10
rearrangement in the thymus, cells proliferate at the DN3 to DN4 stage and upregulate CD4 and CD8 coreceptors to become CD4+CD8+ DP thymocytes.
Positive_regulation (upregulate) of CD4 in thymus
17) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.10 Pain Relevance 0
These antigen-specific and differentiated CD4+IFN?
Positive_regulation (differentiated) of CD4
18) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2853576 Disease Relevance 0.16 Pain Relevance 0.05
Surprisingly, in our model, no increase in CD4+ T cell activation was observed.
Positive_regulation (activation) of CD4 in T cell
19) Confidence 0.42 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2852613 Disease Relevance 0.96 Pain Relevance 0.04
Examination of immunological parameters revealed a transient decrease in CD25(+) peripheral blood lymphocytes and, in seven of eight patients, an increase in CD4(+):CD8(+) ratios at 2 weeks.
Positive_regulation (increase) of CD4 in lymphocytes
20) Confidence 0.42 Published 1997 Journal Clin. Cancer Res. Section Abstract Doc Link 9815786 Disease Relevance 0.85 Pain Relevance 0.09

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