INT22901

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Context Info
Confidence 0.42
First Reported 1990
Last Reported 2010
Negated 8
Speculated 1
Reported most in Body
Documents 30
Total Number 31
Disease Relevance 20.92
Pain Relevance 6.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Anatomy Link Frequency
mammary glands 2
radial 2
lymphocytes 2
MCF-7 2
apoptotic cell 2
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 32 100.00 Very High Very High Very High
Cannabinoid 10 99.92 Very High Very High Very High
agonist 291 99.84 Very High Very High Very High
Inflammation 395 98.40 Very High Very High Very High
Arthritis 790 98.32 Very High Very High Very High
dexamethasone 48 97.32 Very High Very High Very High
ischemia 157 96.28 Very High Very High Very High
metalloproteinase 4 94.08 High High
imagery 10 94.04 High High
Hippocampus 29 93.84 High High
Disease Link Frequency Relevance Heat
Stress 145 100.00 Very High Very High Very High
Targeted Disruption 114 100.00 Very High Very High Very High
Repression 7 100.00 Very High Very High Very High
Infection 65 99.60 Very High Very High Very High
Apoptosis 207 99.52 Very High Very High Very High
Cancer 439 99.40 Very High Very High Very High
Death 142 98.92 Very High Very High Very High
Disease 148 98.76 Very High Very High Very High
Arthritis 430 98.44 Very High Very High Very High
INFLAMMATION 442 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In ER-positive mammary tumors from Wnt-1 transgenic mice, tamoxifen treatment resulted in significant reduction of ER expression [21].
Negative_regulation (reduction) of Gene_expression (expression) of ER associated with targeted disruption and cancer
1) Confidence 0.42 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.22 Pain Relevance 0
Diminished ER expression by tamoxifen treatment has previously been reported in a Wnt-1 model [21].
Negative_regulation (Diminished) of Gene_expression (expression) of ER
2) Confidence 0.42 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.00 Pain Relevance 0
knockout mice where the ER?
Negative_regulation (where) of Gene_expression (knockout) of ER associated with targeted disruption
3) Confidence 0.40 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.48 Pain Relevance 0.46
RESULTS: The study group showed a significant decrease in estrogen receptor expression, and 50% of the samples did not exhibit any receptor expression.
Negative_regulation (decrease) of Gene_expression (expression) of estrogen receptor
4) Confidence 0.40 Published 2003 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 14520218 Disease Relevance 0.09 Pain Relevance 0
but not ER?
Neg (not) Negative_regulation (not) of Gene_expression (but) of ER
5) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.78 Pain Relevance 0.47
but not ER?
Neg (not) Negative_regulation (not) of Gene_expression (but) of ER
6) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.16 Pain Relevance 0.62
but not ER?
Neg (not) Negative_regulation (not) of Gene_expression (but) of ER
7) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.83 Pain Relevance 0.47
but not ER?
Neg (not) Negative_regulation (not) of Gene_expression (but) of ER
8) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.34 Pain Relevance 0.62
receptor expression in ER?
Negative_regulation (receptor) of Gene_expression (expression) of ER
9) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.61 Pain Relevance 0.18
Interestingly, ERA-63 dose-dependently decreased the TT-specific response whereas treatment with the ER?
Negative_regulation (decreased) of Gene_expression (dose) of ERA-63
10) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.61 Pain Relevance 0.34
but not ER?
Neg (not) Negative_regulation (not) of Gene_expression (but) of ER
11) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.21 Pain Relevance 0.31
Moreover, we observed significantly decreased serum COMP levels in the ERA-63 and EE-treated mice.
Negative_regulation (decreased) of Gene_expression (levels) of ERA-63
12) Confidence 0.35 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 1.41 Pain Relevance 0.66
Raloxifene acts mainly via ER?
Negative_regulation (mainly) of Gene_expression (acts) of ER
13) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC3009959 Disease Relevance 1.12 Pain Relevance 0.35
The purpose of the present study was to: (1) investigate whether Delta(9)-tetrahydrocannabinol (Delta(9)-THC) and its analogs [Delta(8)-tetrahydrocannabinol (Delta(8)-THC), HU-210, CP 55,940, and WIN 55,212-2] can prevent the DOI-induced behaviors and (2) to see whether any correlation exists in the ID(50) potency order of these cannabinoids in inhibiting the DOI-induced HTR and ESR relative to their published ED(50) potency profiles in producing the tetrad of behaviors in mice.
Negative_regulation (inhibiting) of Gene_expression (producing) of ESR associated with cannabinoid and potency
14) Confidence 0.32 Published 2001 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11267636 Disease Relevance 0 Pain Relevance 0.42
To determine ER and PR expression in reconstituted mammary glands, the same procedures were performed in four untreated Swiss nu/nu mice, BALB/c or C57BL/6 mice.


Spec (determine) Negative_regulation (determine) of Spec (determine) Gene_expression (expression) of ER in mammary glands
15) Confidence 0.31 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0 Pain Relevance 0.05
showed increased adipogenesis, an effect that was markedly inhibited by coexpression of ER?
Negative_regulation (inhibited) of Gene_expression (coexpression) of ER
16) Confidence 0.29 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0
-deficient mice improved glucose and insulin metabolism supporting the diabetogenic effect of ER?
Negative_regulation (supporting) of Gene_expression (effect) of ER
17) Confidence 0.29 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.38 Pain Relevance 0.08
was reversed by titration of the p160 coactivators, SRC1 and TIF2, suggesting that the suppressive action of ER?
Negative_regulation (suppressive) of Gene_expression (action) of ER
18) Confidence 0.29 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.17 Pain Relevance 0.04
In MCF-7CLU cells the changes in ERalpha expression are substantially reduced but not completely abrogated (Figure 4 panel B).
Neg (not) Negative_regulation (reduced) of Gene_expression (expression) of ERalpha
19) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.46 Pain Relevance 0
In MCF-7CLU cells the changes in ERalpha expression are substantially reduced but not completely abrogated (Figure 4 panel B).
Neg (not) Negative_regulation (abrogated) of Gene_expression (expression) of ERalpha
20) Confidence 0.27 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2856549 Disease Relevance 0.47 Pain Relevance 0

General Comments

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