INT22906

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Context Info
Confidence 0.45
First Reported 1990
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 5
Disease Relevance 5.42
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ggt1) transferase activity, transferring acyl groups (Ggt1)
Anatomy Link Frequency
bile duct 2
liver 1
Ggt1 (Mus musculus)
Pain Link Frequency Relevance Heat
isoflurane 5 99.02 Very High Very High Very High
Bile 84 98.68 Very High Very High Very High
Inflammation 6 86.48 High High
Paracetamol 3 75.00 Quite High
ketamine 2 75.00 Quite High
anesthesia 1 75.00 Quite High
Pain 3 54.40 Quite High
adenocard 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gallstones 249 99.88 Very High Very High Very High
Injury 11 99.30 Very High Very High Very High
Cirrhosis 2 98.76 Very High Very High Very High
Syndrome 96 98.40 Very High Very High Very High
Apoptosis 4 94.96 High High
Biliary Liver Cirrhosis 12 90.56 High High
Pancreatitis 12 90.00 High High
Disease 30 88.92 High High
Cholangitis 12 87.52 High High
Cholecystitis 6 87.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of IF had no effect on hepatic enzyme activities, and GGT was not increased after administration of any of the agents.
Neg (not) Positive_regulation (increased) of GGT associated with isoflurane
1) Confidence 0.45 Published 2002 Journal Comp. Med. Section Abstract Doc Link 11900415 Disease Relevance 0.46 Pain Relevance 0.33
Intrahepatic gallstones or sludge and increased serum gamma-glutamyl transferase (GGT) activity are frequently present.
Positive_regulation (increased) of GGT associated with gallstones
2) Confidence 0.45 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1910597 Disease Relevance 2.25 Pain Relevance 0.14
Defect in ABCB4 function causes the production of bile with low phospholipid content, increased lithogenicity and high detergent properties leading to bile duct luminal membrane injuries and resulting in cholestasis with increased serum gamma-glutamyltransferase (GGT) activity.
Positive_regulation (increased) of GGT in bile duct associated with bile, injury and gallstones
3) Confidence 0.45 Published 2007 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1910597 Disease Relevance 1.32 Pain Relevance 0.14
Defect in ABCB4 function causes the production of bile with low phospholipid content, increased lithogenicity and high detergent properties leading to bile duct luminal membrane injuries and resulting in cholestasis with increased serum GGT activity.
Positive_regulation (increased) of GGT in bile duct associated with bile, injury and gallstones
4) Confidence 0.45 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC1910597 Disease Relevance 1.08 Pain Relevance 0.13
Despite a slight enhancement of focal liver lesions positive for gamma-glutamyltranspeptidase (GGT), no significant promotion of GST-P-positive altered foci or nodules was observed.
Positive_regulation (enhancement) of gamma-glutamyltranspeptidase in liver
5) Confidence 0.06 Published 1990 Journal Carcinogenesis Section Abstract Doc Link 2347065 Disease Relevance 0.32 Pain Relevance 0.19

General Comments

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