INT22907

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Context Info
Confidence 0.67
First Reported 1982
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 33
Total Number 35
Disease Relevance 17.82
Pain Relevance 5.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ggt1) aging (Ggt1) transferase activity, transferring acyl groups (Ggt1)
Anatomy Link Frequency
liver 8
bile 3
plasma 1
hepatocytes 1
BBM 1
Ggt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 4 100.00 Very High Very High Very High
Paracetamol 32 99.98 Very High Very High Very High
depression 61 99.96 Very High Very High Very High
Bile 42 99.84 Very High Very High Very High
fluoxetine 10 99.70 Very High Very High Very High
alcohol 66 99.12 Very High Very High Very High
Pain 57 99.10 Very High Very High Very High
headache 11 98.12 Very High Very High Very High
dexamethasone 7 97.88 Very High Very High Very High
backache 4 97.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 55 100.00 Very High Very High Very High
Depression 125 99.96 Very High Very High Very High
Gallstones 90 99.70 Very High Very High Very High
Infection 9 99.66 Very High Very High Very High
Liver Cancer 21 99.44 Very High Very High Very High
Cirrhosis 4 99.30 Very High Very High Very High
Pain 58 99.10 Very High Very High Very High
Hepatotoxicity 16 98.88 Very High Very High Very High
Biliary Liver Cirrhosis 17 98.64 Very High Very High Very High
Nicotine Addiction 9 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Induction of gamma-glutamyl transpeptidase in primary cultures of normal rat hepatocytes by liver tumor promoters and structurally related compounds.
Positive_regulation (Induction) of gamma-glutamyl transpeptidase in hepatocytes associated with liver cancer
1) Confidence 0.67 Published 1985 Journal Carcinogenesis Section Title Doc Link 2860980 Disease Relevance 0.10 Pain Relevance 0.16
Hepatic GGT activity was increased slightly, but not significantly, whereas renal GGT activity was similar in ethanol-fed rats.
Positive_regulation (increased) of GGT
2) Confidence 0.67 Published 1986 Journal Biochem. Pharmacol. Section Abstract Doc Link 2871842 Disease Relevance 0.12 Pain Relevance 0.10
Total mRNA isolated from diabetic and insulin-treated diabetic rat livers did not conclusively demonstrate an elevation of GGT mRNA relative to normal.
Positive_regulation (elevation) of GGT in livers associated with diabetes mellitus
3) Confidence 0.67 Published 1998 Journal J. Biochem. Mol. Toxicol. Section Abstract Doc Link 9580874 Disease Relevance 1.03 Pain Relevance 0.06
When added to cultures for 5 days, a variety of xenobiotics and steroids increased GGT activity to levels 2- to 6-times those of control cultures.
Positive_regulation (increased) of GGT
4) Confidence 0.67 Published 1985 Journal Carcinogenesis Section Abstract Doc Link 2860980 Disease Relevance 0.07 Pain Relevance 0.14
GGT activity was increased by diabetes in liver canalicular-enriched and basolateral-enriched membrane preparations, and it was unchanged in renal brush border-enriched membranes.
Positive_regulation (increased) of GGT in brush associated with diabetes mellitus
5) Confidence 0.67 Published 1998 Journal J. Biochem. Mol. Toxicol. Section Abstract Doc Link 9580874 Disease Relevance 1.09 Pain Relevance 0.07
Despite a slight enhancement of focal liver lesions positive for gamma-glutamyltranspeptidase (GGT), no significant promotion of GST-P-positive altered foci or nodules was observed.
Positive_regulation (enhancement) of GGT in liver
6) Confidence 0.49 Published 1990 Journal Carcinogenesis Section Abstract Doc Link 2347065 Disease Relevance 0.32 Pain Relevance 0.19
Liver function was assessed in serum by measuring alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase activities (Bergmeyer and Horder 1980).
Positive_regulation (measuring) of gamma-glutamyl transferase in Liver
7) Confidence 0.49 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440770 Disease Relevance 0 Pain Relevance 0
Acetaminophen induced a significant rise in aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), total bilirubin, gamma glutamate transpeptidase (GGTP), lipid peroxidase (LPO) with a reduction of total protein, superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione S-transferase (GST).
Positive_regulation (induced) of GGTP associated with glutamate and paracetamol
8) Confidence 0.48 Published 2008 Journal Pak J Pharm Sci Section Abstract Doc Link 18166521 Disease Relevance 0.17 Pain Relevance 0.39
A significant increased prevalence of abnormal gamma-glutamyl transpeptidase (GGT) and higher mean GGT were found in those with chloracne, compared to those without.
Positive_regulation (increased) of gamma-glutamyl transpeptidase associated with chloracne
9) Confidence 0.46 Published 1984 Journal Am. J. Ind. Med. Section Abstract Doc Link 6142642 Disease Relevance 0.90 Pain Relevance 0.07
Statistically significant increases were observed in alkaline phosphatase (1.1–8.9 U/L), GGT (1.3–11.0 U/L), AST (1.6–2.9 U/L), ALT (3.9–4.2 U/L), total cholesterol (0.10–0.23 mmol/L), HDL (0.035–0.060 mmol/L), low-density lipoproteins (LDL; 0.05–0.17 mmol/L), and triglycerides (0.11–0.13 mmol/L).
Positive_regulation (increases) of GGT associated with disorder of lipid metabolism
10) Confidence 0.45 Published 2010 Journal Core evidence Section Body Doc Link PMC2899788 Disease Relevance 0.58 Pain Relevance 0.10
FN significantly (P < 0.05) increased GGT(+) foci number/cm(2) and number/cm(3), while FX significantly increased GGT(+) foci number/cm(2) and the volume fraction of foci.
Positive_regulation (increased) of GGT associated with fluoxetine
11) Confidence 0.45 Published 1999 Journal Carcinogenesis Section Abstract Doc Link 10469626 Disease Relevance 0.41 Pain Relevance 0.49
Densitometric quantification demonstrated that hepatic GGT activity in diabetic rats was significantly increased when compared to normal and insulin-treated diabetic controls.
Positive_regulation (increased) of GGT associated with diabetes mellitus
12) Confidence 0.45 Published 1998 Journal J. Biochem. Mol. Toxicol. Section Abstract Doc Link 9580874 Disease Relevance 1.01 Pain Relevance 0.08
These data indicate that streptozotocin-induced diabetes does not alter the expression of, but does increase the activity of, GGT in liver.
Positive_regulation (increase) of GGT in liver associated with diabetes mellitus
13) Confidence 0.45 Published 1998 Journal J. Biochem. Mol. Toxicol. Section Abstract Doc Link 9580874 Disease Relevance 1.03 Pain Relevance 0
In control cultures GGT activity was low and increased slowly with time.
Positive_regulation (increased) of GGT
14) Confidence 0.45 Published 1985 Journal Carcinogenesis Section Abstract Doc Link 2860980 Disease Relevance 0.07 Pain Relevance 0.08
In contrast, continuous feeding of CD diet or 0.5% phenobarbital treatment after generation of cirrhosis with CD diet clearly enhanced the induction of both GST-P and GGT-positive liver lesions.
Positive_regulation (induction) of GGT in liver associated with cirrhosis
15) Confidence 0.45 Published 1990 Journal Carcinogenesis Section Abstract Doc Link 2347065 Disease Relevance 0.26 Pain Relevance 0.07
Induction of GGT was potentiated for most test compounds by 20-30 nM dexamethasone and diminished by nicotinamide or adenosine-3',5'-monophosphate.
Positive_regulation (Induction) of GGT associated with adenocard and dexamethasone
16) Confidence 0.45 Published 1985 Journal Carcinogenesis Section Abstract Doc Link 2860980 Disease Relevance 0.07 Pain Relevance 0.18
Except for 2-acetylaminofluorene and diethylnitrosamine, genotoxic compounds tested did not increase GGT.
Neg (not) Positive_regulation (increase) of GGT
17) Confidence 0.45 Published 1985 Journal Carcinogenesis Section Abstract Doc Link 2860980 Disease Relevance 0.17 Pain Relevance 0.22
A number of compounds including barbituric acid, butyl hydroxyanisole, acetaminophen, saccharin, caffeine, clofibrate and some bile acids failed to induce GGT.
Neg (failed) Positive_regulation (induce) of GGT in bile associated with bile and paracetamol
18) Confidence 0.45 Published 1985 Journal Carcinogenesis Section Abstract Doc Link 2860980 Disease Relevance 0.16 Pain Relevance 0.23
Thus, a variety of compounds used in experimental studies of liver cancer induction as promoters may elevate GGT by mechanism(s) not necessarily related to carcinogenesis.
Neg (not) Spec (may) Positive_regulation (elevate) of GGT in liver associated with liver cancer
19) Confidence 0.45 Published 1985 Journal Carcinogenesis Section Abstract Doc Link 2860980 Disease Relevance 0.27 Pain Relevance 0.18
The results showed that plasma gamma-glutamyl transpeptidase and alanine aminotransferase activity was increased by bile-duct ligation, and that L-aginine treatment partially, but significantly, prevented the elevation of these markers of liver damage.
Positive_regulation (increased) of plasma gamma-glutamyl transpeptidase in bile associated with bile and hepatotoxicity
20) Confidence 0.45 Published 2001 Journal Eur. J. Pharmacol. Section Abstract Doc Link 11137868 Disease Relevance 0.59 Pain Relevance 0.17

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