INT229094

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.90
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (IL1RN, Il1r1) protein complex (Il1r1) signal transducer activity (Il1r1)
cytoplasm (IL1RN) extracellular space (IL1RN) signal transduction (Il1r1)
IL1RN (Homo sapiens)
Il1r1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 42 100.00 Very High Very High Very High
cytokine 36 100.00 Very High Very High Very High
Inflammation 105 87.68 High High
anakinra 12 79.28 Quite High
rheumatoid arthritis 18 73.68 Quite High
Arthritis 6 65.84 Quite High
withdrawal 15 5.00 Very Low Very Low Very Low
Inflammatory marker 9 5.00 Very Low Very Low Very Low
depression 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 126 88.44 High High
INFLAMMATION 114 87.68 High High
Rheumatoid Arthritis 21 73.68 Quite High
Arthritis 12 65.84 Quite High
Disease 9 64.32 Quite High
Syndrome 3 55.68 Quite High
Myocardial Infarction 21 39.48 Quite Low
Atherosclerosis 36 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 36 5.00 Very Low Very Low Very Low
Coronary Artery Disease 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
that signal via the Type 1 IL-1 receptor (IL-1R1) and a specific Interleukin-1 receptor antagonist (IL-1ra), (the only known naturally occurring cytokine antagonist) that inhibits IL-1 actions by binding to the IL-1R1, blocking the receptor and preventing IL-1 from binding thereby preventing receptor signalling [7].
IL-1ra Binding (binding) of IL-1R1 associated with antagonist and cytokine
1) Confidence 0.01 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.64 Pain Relevance 0.50
that signal via the Type 1 IL-1 receptor (IL-1R1) and a specific Interleukin-1 receptor antagonist (IL-1ra), (the only known naturally occurring cytokine antagonist) that inhibits IL-1 actions by binding to the IL-1R1, blocking the receptor and preventing IL-1 from binding thereby preventing receptor signalling [7].
antagonist Binding (binding) of IL-1R1 associated with antagonist and cytokine
2) Confidence 0.01 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.63 Pain Relevance 0.50
that signal via the Type 1 IL-1 receptor (IL-1R1) and a specific Interleukin-1 receptor antagonist (IL-1ra), (the only known naturally occurring cytokine antagonist) that inhibits IL-1 actions by binding to the IL-1R1, blocking the receptor and preventing IL-1 from binding thereby preventing receptor signalling [7].
antagonist Binding (binding) of IL-1R1 associated with antagonist and cytokine
3) Confidence 0.01 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.64 Pain Relevance 0.50

General Comments

This test has worked.

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