INT229095

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.64
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (IL1R1, Il1r1) signal transducer activity (IL1R1, Il1r1) signal transduction (Il1r1)
extracellular region (IL1R1) plasma membrane (IL1R1) protein complex (Il1r1)
IL1R1 (Homo sapiens)
Il1r1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 14 100.00 Very High Very High Very High
cytokine 12 100.00 Very High Very High Very High
Inflammation 35 87.68 High High
anakinra 4 79.28 Quite High
rheumatoid arthritis 6 73.68 Quite High
Arthritis 2 65.84 Quite High
withdrawal 5 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acute Coronary Syndrome 42 89.36 High High
INFLAMMATION 38 87.68 High High
Rheumatoid Arthritis 7 73.68 Quite High
Arthritis 4 65.84 Quite High
Disease 3 64.32 Quite High
Syndrome 1 55.68 Quite High
Myocardial Infarction 7 40.40 Quite Low
Atherosclerosis 12 5.00 Very Low Very Low Very Low
Adverse Drug Reaction 12 5.00 Very Low Very Low Very Low
Coronary Artery Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
that signal via the Type 1 IL-1 receptor (IL-1R1) and a specific Interleukin-1 receptor antagonist (IL-1ra), (the only known naturally occurring cytokine antagonist) that inhibits IL-1 actions by binding to the IL-1R1, blocking the receptor and preventing IL-1 from binding thereby preventing receptor signalling [7].
Interleukin-1 receptor Binding (binding) of IL-1R1 associated with antagonist and cytokine
1) Confidence 0.00 Published 2008 Journal Trials Section Body Doc Link PMC2289802 Disease Relevance 0.64 Pain Relevance 0.50

General Comments

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