INT229110

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.08
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (DIO2) plasma membrane (DIO2) cellular nitrogen compound metabolic process (DIO2)
Anatomy Link Frequency
neural 2
DIO2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 464 99.50 Very High Very High Very High
Catechol-O-methyltransferase 17 95.36 Very High Very High Very High
Neurotransmitter 27 91.00 High High
agonist 124 86.64 High High
drug abuse 2 78.44 Quite High
alcohol 12 73.28 Quite High
Pyramidal cell 12 69.08 Quite High
tolerance 3 66.96 Quite High
Nicotine 7 56.76 Quite High
opiate 3 55.64 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 9 78.44 Quite High
Parkinson's Disease 43 73.16 Quite High
Muscle Hypotonia 6 70.84 Quite High
Hyperkinesis 7 70.00 Quite High
Disease 26 67.44 Quite High
Attention Deficit Hyperactivity Disorder 54 60.00 Quite High
Obesity 31 55.84 Quite High
Cognitive Disorder 18 53.84 Quite High
Syndrome 22 50.00 Quite Low
Schizophrenia 2 49.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The nanomolar concentrations of dopamine interact preferentially with D1 receptors (dissociation constant 740 nM (Niznik et al. 1986, p. 8401), whereas micromolar concentrations are needed for prominent D2 receptor activation (dissociation constant 117 ?
Positive_regulation (prominent) of Positive_regulation (activation) of D2 associated with dopamine
1) Confidence 0.26 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.20 Pain Relevance 0.48
The nanomolar concentrations of dopamine interact preferentially with D1 receptors (dissociation constant 740 nM (Niznik et al. 1986, p. 8401), whereas micromolar concentrations are needed for prominent D2 receptor activation (dissociation constant 117 ?
Positive_regulation (needed) of Positive_regulation (activation) of D2 associated with dopamine
2) Confidence 0.26 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.20 Pain Relevance 0.51
As dopamine release is acutely impaired, synaptic concentration cannot achieve a level necessary for micromolar D2 activation.
Positive_regulation (necessary) of Positive_regulation (activation) of D2 associated with dopamine
3) Confidence 0.21 Published 2010 Journal J Neural Transm Section Body Doc Link PMC3000910 Disease Relevance 0.13 Pain Relevance 0.21
This molecular finding serves as the basis for inducing DA release naturally, also causing the same induction of D2-directed mRNA and thus proliferation of D2 receptors in the human.
Positive_regulation (causing) of Positive_regulation (induction) of D2 associated with dopamine
4) Confidence 0.14 Published 2008 Journal Theor Biol Med Model Section Body Doc Link PMC2615745 Disease Relevance 0.44 Pain Relevance 0.50
This leads to an increase in D2 and a decrease in D1 receptor transmission; as a result there is decreased stability of neural networks, underlying working memory representations.
Positive_regulation (leads) of Positive_regulation (increase) of D2 in neural
5) Confidence 0.04 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2289834 Disease Relevance 0.11 Pain Relevance 0.61

General Comments

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