INT229152

Context Info Confidence 0.19 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 1.35 Pain Relevance 0.08

endosome (Abcg1) transport (Abcg1) Golgi apparatus (Abcg1) ATPase activity (Abcg1) plasma membrane (Abcg1) intracellular (Abcg1)

Anatomy Link Frequency Macrophages 1 Abcg1 (Mus musculus)

Pain Link Frequency Relevance Heat GABAergic 11 77.36 interneuron 7 76.56 agonist 15 36.00 imagery 19 5.00 Pyramidal cell 14 5.00 alcohol 11 5.00 Inflammation 10 5.00 Bile 4 5.00 ketamine 3 5.00 gABA 3 5.00

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 288 99.32 Targeted Disruption 16 90.24 Atherosclerosis 49 83.12 Atherosclerotic Plaque 3 74.96 Hypolipidemia 2 45.76 Insulin Resistance 2 42.96 Metabolic Syndrome 1 40.80 Coronary Heart Disease 33 5.00 Myocardial Infarction 19 5.00 Cardiovascular Disease 11 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

HDL (Kennedy et al 2005) Macrophages deficient in ABCG1 also have impaired FC efflux and accumulate excess cholesterol (Out R 2006).

Negative_regulation (deficient) of ABCG1 in Macrophages associated with disorder of lipid metabolism

1) Confidence 0.19 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464766 Disease Relevance 1.35 Pain Relevance 0

We engineered adeno-associated viruses (AAVs) that express GFP, dsRedExpress, or channelrhodopsin (ChR2) upon Cre/loxP recombination-mediated removal of a transcription-translation STOP cassette.

Negative_regulation (removal) of cassette

2) Confidence 0.01 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2289876 Disease Relevance 0 Pain Relevance 0.08

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