INT22916

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Context Info
Confidence 0.57
First Reported 1990
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.31
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
erythrocyte 2
nerve 1
CR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 5 98.88 Very High Very High Very High
spinal inflammation 8 98.72 Very High Very High Very High
Arthritis 6 98.68 Very High Very High Very High
rheumatoid arthritis 14 98.20 Very High Very High Very High
Analgesic 2 97.96 Very High Very High Very High
antagonist 29 95.60 Very High Very High Very High
agonist 48 90.40 High High
medulla 1 89.16 High High
Dopamine 1 88.64 High High
Kinase C 1 86.16 High High
Disease Link Frequency Relevance Heat
Rheumatic Diseases 8 98.88 Very High Very High Very High
Pain 5 98.88 Very High Very High Very High
Low Back Pain 8 98.72 Very High Very High Very High
Crystal Associated Disease 2 98.68 Very High Very High Very High
Rheumatoid Arthritis 14 98.56 Very High Very High Very High
Sprains And Strains 122 98.06 Very High Very High Very High
Herpes Simplex Encephalitis 3 98.04 Very High Very High Very High
Arthritis 4 97.08 Very High Very High Very High
Syndrome 2 96.92 Very High Very High Very High
Herpes Simplex Virus 3 93.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CD19, CD20, CD21, CD22, CD35 receptors were found to be diminished.
Negative_regulation (diminished) of CD35
1) Confidence 0.57 Published 2004 Journal Acta Medica (Hradec Kralove) Section Abstract Doc Link 15168883 Disease Relevance 0.99 Pain Relevance 0.13
Further, the binding to sCR1-coated microspheres was inhibited by chicken anti-CR1 whereas the binding to BSA-coated microspheres was not inhibited by polyclonal rabbit anti-BSA.


Negative_regulation (inhibited) of CR1
2) Confidence 0.40 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.23 Pain Relevance 0
Using the prototypical sialic acid-independent strain 7G8, we demonstrated that sCR1 as well as polyclonal and monoclonal antibodies directed against CR1 drastically reduced or eliminated sialic acid-independent invasion while control proteins and antibodies did not.
Negative_regulation (reduced) of CR1 associated with sprains and strains
3) Confidence 0.35 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.57 Pain Relevance 0
Therefore, J3B11 appears to be s binding closest to the ligand binding site in CR1.


Negative_regulation (site) of CR1
4) Confidence 0.35 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2887475 Disease Relevance 0.31 Pain Relevance 0
In contrast, the oxidative burst induced by opsonized H. pylori without NAC was not inhibited by rebamipide, which might indicate that it does not have the ability to block CR1 or CR3 receptors involved in opsonic phagocytosis but still has the ability to block the receptor(s) for NAC.
Negative_regulation (block) of CR1
5) Confidence 0.33 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9753245 Disease Relevance 0.41 Pain Relevance 0.11
Membrane-bound CRegs (Fig. 1) include decay-accelerating factor (DAF, CD55), membrane co-factor protein (MCP, CD46), complement receptor 1 (CR1, CD35), and membrane inhibitor of reactive lysis (MIRL, CD59).
Negative_regulation (inhibitor) of complement receptor 1
6) Confidence 0.23 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0 Pain Relevance 0
This suggests that erythrocyte CR1 deficiency may occur in immune-mediated rheumatic diseases such as crystal-induced arthritis.
Negative_regulation (deficiency) of CR1 in erythrocyte associated with rheumatic diseases and arthritis
7) Confidence 0.23 Published 1990 Journal Rheumatol. Int. Section Abstract Doc Link 2349436 Disease Relevance 1.78 Pain Relevance 0.71
The levels of erythrocyte CR1 decreased significantly in patients with AS, juvenile rheumatoid arthritis, Sjögren's syndrome, and RA, while there was no statistical difference in levels of erythrocyte CR1 between normal controls and patients with gouty arthritis.
Negative_regulation (decreased) of CR1 in erythrocyte associated with spinal inflammation, syndrome, rheumatoid arthritis, crystal associated disease and arthritis
8) Confidence 0.20 Published 1990 Journal Rheumatol. Int. Section Abstract Doc Link 2349436 Disease Relevance 1.67 Pain Relevance 0.65
In addition the negative values of (CR-1) obtained in the presence of the extract and carvacrol are another indicator of stimulatory effect of the plant and its constituent on ?
Negative_regulation (values) of CR-1
9) Confidence 0.07 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997514 Disease Relevance 0 Pain Relevance 0
The isoquinoline KN62 (calmodulin kinase II and P2X7 receptor inhibitor; Calbiochem) was used at 10 ?
Negative_regulation (inhibitor) of KN62
10) Confidence 0.00 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.09
Failure of KN62 to inhibit LPS-induced IL-1?
Negative_regulation (Failure) of KN62
11) Confidence 0.00 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0 Pain Relevance 0.06
This action is due to the inhibition of peripheral CCK1 type receptor in the central descending nerve pathway, facilitating pain transmission in sheep perhaps in the hypothalamic-pituitary-adrenal axis.
Negative_regulation (inhibition) of CCK1 type receptor in nerve associated with pain
12) Confidence 0.00 Published 2005 Journal Pol J Vet Sci Section Abstract Doc Link 16180579 Disease Relevance 0.34 Pain Relevance 0.67

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