INT229177

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.68
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (IFRD1, TP53) cell differentiation (TP53) nucleoplasm (TP53)
mitochondrion (TP53) endoplasmic reticulum (TP53) enzyme binding (TP53)
Anatomy Link Frequency
myoblast 2
IFRD1 (Homo sapiens)
TP53 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 2 85.12 High High
Inflammation 4 61.36 Quite High
Inflammatory response 4 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 10 98.96 Very High Very High Very High
INFLAMMATION 8 61.36 Quite High
Diabetes Mellitus 24 57.60 Quite High
Nervous System Malformation 2 47.32 Quite Low
Hypoxia 2 37.96 Quite Low
Apoptosis 14 22.84 Low Low
Toxicity 2 5.12 Low Low
Nicotine Addiction 18 5.00 Very Low Very Low Very Low
Cancer 18 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Notably, TP53 regulates intercellular adhesion molecule 1 (ICAM-1), which controls immune cell migration and adhesion, and interferon-related developmental regulator 1 (IFRD1/PC4), which regulates p53 transcriptional activity and is required for myoblast differentiation, and also inhibits MyoD and MADS box transcription enhancer factor 2, polypeptide C (MEF2C) (Batta and Kundu 2007; Gorgoulis et al. 2005; Micheli et al. 2005; Nery et al. 2006).
PC4 Regulation (regulates) of p53 in myoblast associated with adhesions
1) Confidence 0.13 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2290973 Disease Relevance 0.31 Pain Relevance 0.12
Notably, TP53 regulates intercellular adhesion molecule 1 (ICAM-1), which controls immune cell migration and adhesion, and interferon-related developmental regulator 1 (IFRD1/PC4), which regulates p53 transcriptional activity and is required for myoblast differentiation, and also inhibits MyoD and MADS box transcription enhancer factor 2, polypeptide C (MEF2C) (Batta and Kundu 2007; Gorgoulis et al. 2005; Micheli et al. 2005; Nery et al. 2006).
IFRD1 Regulation (regulates) of p53 in myoblast associated with adhesions
2) Confidence 0.13 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2290973 Disease Relevance 0.37 Pain Relevance 0.12

General Comments

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