INT22919

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Context Info
Confidence 0.55
First Reported 1980
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 18
Total Number 20
Disease Relevance 6.84
Pain Relevance 7.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cellular_component (Gpt) biological_process (Gpt)
cytoplasm (Gpt)
Anatomy Link Frequency
plasma 2
liver 2
blood 1
hepatocyte 1
internal 1
Gpt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 93 100.00 Very High Very High Very High
Glutamate 22 100.00 Very High Very High Very High
halothane 8 98.20 Very High Very High Very High
Nicotine 9 95.96 Very High Very High Very High
tetrodotoxin 5 88.44 High High
sodium channel 1 86.04 High High
cINOD 1 82.96 Quite High
Inflammatory response 1 78.56 Quite High
Action potential 4 77.28 Quite High
Inflammatory mediators 1 74.48 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 46 99.62 Very High Very High Very High
Injury 43 98.16 Very High Very High Very High
Death 7 96.00 Very High Very High Very High
Body Weight 14 95.48 Very High Very High Very High
Poisoning 6 95.44 Very High Very High Very High
Burns 22 90.16 High High
Liver Disease 6 89.68 High High
Infection 3 87.68 High High
Hepatitis 2 87.20 High High
Cirrhosis 1 86.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of rats with plant extract (150 mg/kg) lowered significantly the respective serum GOT and GPT levels to 85 +/- 11 and 23 +/- 06. 5.
Negative_regulation (lowered) of GPT
1) Confidence 0.55 Published 1993 Journal Gen. Pharmacol. Section Abstract Doc Link 8112519 Disease Relevance 0.25 Pain Relevance 0.33
However, when a dose of 300 micrograms/kg of colchicine was given, levels of lipid peroxidation and serum gamma-GTP activity remained within the control values, while GPT activity and glycogen content were only partially attenuated.
Spec (partially) Negative_regulation (attenuated) of GPT
2) Confidence 0.42 Published 1993 Journal Liver Section Abstract Doc Link 8377598 Disease Relevance 0.49 Pain Relevance 0.73
Pretreatment of rats with plant extract (500 mg/kg, orally twice daily for 2 days) prevented (P < 0.001) the paracetamol (640 mg/kg)-induced rise in serum enzymes alkaline phosphatase (ALP) and transaminases (GOT and GPT), whereas the same dose of the extract was unable to prevent (P > 0.05) the CCI4-induced rise in serum enzyme levels. 4.
Negative_regulation (prevented) of GPT associated with paracetamol
3) Confidence 0.41 Published 1996 Journal Gen. Pharmacol. Section Abstract Doc Link 8909978 Disease Relevance 0.17 Pain Relevance 0.44
Pretreatment of rats with plant extract (500 mg/kg, orally twice daily for two days) prevented (P < 0.01) the acetaminophen (640 mg/kg) as well as CCl4 (1.5 ml/kg)-induced rise in serum transaminases (GOT and GPT). 4.
Negative_regulation (prevented) of GPT associated with paracetamol
4) Confidence 0.41 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7590079 Disease Relevance 0.26 Pain Relevance 0.44
Results showed that CHCKT treatments significantly decreased the level of serum glutamic oxaloacetic transaminase (sGOT) and glutamic pyruvic transaminase (sGPT) in APAP-treated groups.
Negative_regulation (decreased) of sGPT associated with paracetamol
5) Confidence 0.41 Published 2007 Journal Am. J. Chin. Med. Section Abstract Doc Link 17265552 Disease Relevance 0.43 Pain Relevance 0.44
Results showed that CHCKT treatments significantly decreased the level of serum glutamic oxaloacetic transaminase (sGOT) and glutamic pyruvic transaminase (sGPT) in APAP-treated groups.
Negative_regulation (decreased) of glutamic pyruvic transaminase associated with paracetamol
6) Confidence 0.41 Published 2007 Journal Am. J. Chin. Med. Section Abstract Doc Link 17265552 Disease Relevance 0.43 Pain Relevance 0.44
To improve the diagnostic value of the ALT assay and to understand the molecular basis for serum ALT changes in various pathophysiological conditions, we have cloned rat ALT isoenzyme ALT1 and ALT2 complementary DNAs (cDNAs), examined their tissue expressions at the messenger RNA and protein levels, and determined ALT1 and ALT 2 serum levels in response to liver damage in rodents.
Spec (determined) Negative_regulation (determined) of ALT1 in liver associated with hepatotoxicity
7) Confidence 0.40 Published 2009 Journal Hepatology Section Abstract Doc Link 19085960 Disease Relevance 0.82 Pain Relevance 0
Such an effect of GPT was concentration-dependent and was apparent in concentrations over 10 nM.
Negative_regulation (effect) of GPT
8) Confidence 0.38 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7143240 Disease Relevance 0 Pain Relevance 0.78
Combined treatment with the two poisons results in a minor alteration of hepatocyte function as shown by the lack of GPT in serum and by the reduced fall of hepatic GSH as well as by a decreased production of TBA-reacting compounds.
Negative_regulation (lack) of GPT in hepatocyte
9) Confidence 0.36 Published 1980 Journal Boll. Soc. Ital. Biol. Sper. Section Abstract Doc Link 7470301 Disease Relevance 0.22 Pain Relevance 0.36
However, simultaneous intubations of some of the rat with 10 mg or 20 mg mL(-1) of T. occidentalis leaf extract (free soluble or bound polyphenols) along side with the acetaminophen caused a significant decrease (p<0.05) in serum ALP, GOT and GPT (except those intubated with bound polyphenols).
Negative_regulation (decrease) of GPT in leaf associated with paracetamol
10) Confidence 0.36 Published 2007 Journal Pak. J. Biol. Sci. Section Abstract Doc Link 19070082 Disease Relevance 0.21 Pain Relevance 0.36
Pretreatment of rats with the plant extract (500 mg/kg) lowered significantly (P < 0.001) the respective serum GOT and GPT levels to 112 +/- 10 I.U.
Negative_regulation (lowered) of GPT
11) Confidence 0.35 Published 1995 Journal J Ethnopharmacol Section Abstract Doc Link 7564420 Disease Relevance 0.24 Pain Relevance 0.47
For the acute administration of chemicals in high doses, in the rat liver microsomes a decrease of cytochrome P450, aniline hydroxylase and glutathione (GSH) was noticed with an increase of lipid peroxides even at 2 hours after administration. 24 hours after the chemicals administration, in the blood of rats characteristic changes of hepatotoxicity such as increases glutamate-pyruvate transminase, triglycerides and lipid peroxides, while GSH was decreased.
Negative_regulation (decreased) of glutamate-pyruvate transminase in blood associated with glutamate and hepatotoxicity
12) Confidence 0.23 Published 2002 Journal Rocz. Akad. Med. Bialymst. Section Abstract Doc Link 12533950 Disease Relevance 0.49 Pain Relevance 0.13
In rats, misoprostol (20-100 micrograms/kg p.o.) markedly reduced early increments of plasma enzyme activities (glutamate-pyruvate-transaminase, GPT; sorbitol dehydrogenase, SDH) in a model of halothane-induced liver injury; the most effective dose in this respect (20 micrograms/kg) significantly depressed halothane-induced ethane exhalation indicating in vivo lipid peroxidation.
Negative_regulation (reduced) of glutamate-pyruvate-transaminase in plasma associated with glutamate, injury and halothane
13) Confidence 0.23 Published 1988 Journal Toxicology Section Abstract Doc Link 3145629 Disease Relevance 0.19 Pain Relevance 0.32
Pretreatment with the methanol extract significantly reduced GPT, GOT and ALKP levels as compared to paracetamol [Table 5].


Negative_regulation (reduced) of GPT associated with paracetamol
14) Confidence 0.22 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2900060 Disease Relevance 0.23 Pain Relevance 0.18
The administration of Calendula officinalis extract significantly decreased the serum level of marker enzymes of tissue damage like ALP, GOT and GPT indicating that Calendula extract reduce the injury of the internal organs during thermal burning.
Negative_regulation (decreased) of GPT in internal associated with injury
15) Confidence 0.20 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2533690 Disease Relevance 1.04 Pain Relevance 0.16
In rats, misoprostol (20-100 micrograms/kg p.o.) markedly reduced early increments of plasma enzyme activities (glutamate-pyruvate-transaminase, GPT; sorbitol dehydrogenase, SDH) in a model of halothane-induced liver injury; the most effective dose in this respect (20 micrograms/kg) significantly depressed halothane-induced ethane exhalation indicating in vivo lipid peroxidation.
Negative_regulation (reduced) of GPT in plasma associated with glutamate, injury and halothane
16) Confidence 0.18 Published 1988 Journal Toxicology Section Abstract Doc Link 3145629 Disease Relevance 0.19 Pain Relevance 0.32
The C chinensis ethanolic extract at an oral dose of both 125 and 250mg/kg showed a significant hepatoprotective effect relatively to the same extent (P<0.05) by reducing levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), and alkaline phosphatase (ALP).
Negative_regulation (reducing) of GPT associated with glutamate
17) Confidence 0.14 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17145147 Disease Relevance 0.43 Pain Relevance 0.53
The results showed that the sGOT and the sGPT activities, increased by APAP, were decreased significantly (P < 0.05) through treatment with inceasing amounts up to 1000 mg/kg body wt. of the exracts.
Negative_regulation (decreased) of sGPT in body
18) Confidence 0.14 Published 2001 Journal Phytomedicine Section Abstract Doc Link 11417915 Disease Relevance 0.26 Pain Relevance 0.19
Pretreatment of rats with plant extract (500 mg/kg) significantly lowered (P < 0.05) the respective serum ALP; GOT and GPT levels to 192 +/- 31, 63 +/- 9 and 35 +/- 8. 5.
Negative_regulation (lowered) of GPT
19) Confidence 0.13 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7789738 Disease Relevance 0.24 Pain Relevance 0.40
It was found that the oil markedly inhibited MDA formation of liver induced by CCl4 and AAP, decreased sGPT levels induced by CCl4 and blocked depletion of GSH damaged liver induced by AAP.LD50 greater than 45.0 g/kg.
Negative_regulation (decreased) of sGPT in liver associated with paracetamol
20) Confidence 0.00 Published 1990 Journal Zhongguo Zhong Yao Za Zhi Section Abstract Doc Link 2350427 Disease Relevance 0.24 Pain Relevance 0.39

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