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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.25
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CREB1) signal transduction (CREB1) mitochondrion (CREB1)
nucleolus (CREB1) nucleus (CREB1) transcription factor binding (CREB1)
Anatomy Link Frequency
brain 2
CREB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 94.84 High High
antidepressant 29 90.96 High High
Hippocampus 1 55.76 Quite High
depression 3 53.80 Quite High
Desipramine 12 36.56 Quite Low
fluoxetine 11 27.96 Quite Low
Serotonin 2 21.76 Low Low
ischemia 10 12.68 Low Low
Inflammation 2 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 11 84.96 Quite High
Depression 3 53.80 Quite High
Stress 5 52.88 Quite High
Stroke 27 50.00 Quite Low
Neuroblastoma 6 50.00 Quite Low
Middle Cerebral Artery Infarction 14 26.32 Quite Low
Brain Hemorrhage 8 15.20 Low Low
Cv General 4 Under Development 5 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, we found that the CaM kinase IV cascade is also involved in the regulation of CREB activation by the mood stabilizer lithium [32].
Regulation (regulation) of Positive_regulation (activation) of CREB
1) Confidence 0.11 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2483719 Disease Relevance 0.11 Pain Relevance 0.17
How these signals confer protection is not completely understood, but working hypotheses include up-regulation of endogenous antioxidant mechanisms in the brain (Toyoda et al. 1997), such as superoxide dismutase (Bordet et al. 2000; Kato et al. 1995; Wada et al. 2001), and activation of transcription factors implicated in neuroprotection, such as cyclic AMP-response element binding protein (CREB) (Hara et al. 2003; Tauskela and Morley 2004) and nuclear factor-kappa B (NF-?
Regulation (regulation) of Positive_regulation (activation) of cyclic AMP-response element binding protein in brain
2) Confidence 0.06 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2291013 Disease Relevance 0.14 Pain Relevance 0.08

General Comments

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