INT229284

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.24
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pck1) nucleus (Pck1) kinase activity (Pck1)
lipid metabolic process (Pck1) cytoplasm (Pck1)
Anatomy Link Frequency
liver 1
Pck1 (Mus musculus)
Pain Link Frequency Relevance Heat
Intracerebroventricular 13 91.16 High High
Bile 39 81.64 Quite High
Cholecystokinin 1 57.52 Quite High
bDMF 6 22.60 Low Low
Central nervous system 3 6.24 Low Low
tolerance 57 5.00 Very Low Very Low Very Low
agonist 35 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fatty Liver 1 100.00 Very High Very High Very High
Hyperglycemia 8 97.80 Very High Very High Very High
Diabetes Mellitus 69 88.80 High High
Insulin Resistance 50 87.20 High High
Obesity 79 83.56 Quite High
Disorder Of Lipid Metabolism 26 82.40 Quite High
Repression 10 78.56 Quite High
Body Weight 35 60.64 Quite High
Coronary Artery Disease 25 50.00 Quite Low
Atherosclerosis 13 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consistently, we observed a moderate increase in hepatic triacylglycerol (TAG) and a 3.5-fold increase in liver fatty acid content after PEPCK-C silencing (Fig. 5B).
Positive_regulation (increase) of PEPCK in liver associated with fatty liver
1) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.27 Pain Relevance 0
The regulation of gluconeogenesis predominantly depends on the expression level of gluconeogenic genes such as PEPCK and G6Pase (31,32).
Positive_regulation (depends) of PEPCK
2) Confidence 0.36 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.58 Pain Relevance 0
target genes involved in triglycerides (TG) synthesis such as lipoprotein lipase (Lpl), phosphoenolpyruvate carboxykinase (PEPCK) and CD36 was significantly upregulated in ?
Positive_regulation (upregulated) of PEPCK
3) Confidence 0.28 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0 Pain Relevance 0
The expression level of PEPCK and Lpl was significantly increased in both wt and ?
Positive_regulation (increased) of PEPCK
4) Confidence 0.26 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432036 Disease Relevance 0.16 Pain Relevance 0
First, we analyzed the expression of an hepatic gene known to be modulated by a central induction of the melanocortin pathway, the phosphenolpyruvate carboxykinase gene (PEPCK), encoding an enzyme involved in hepatic gluconeogenesis.
Positive_regulation (induction) of PEPCK
5) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956692 Disease Relevance 0 Pain Relevance 0.08
Another study suggests that FXR activation actually impairs hepatic gluconeogenic genes such as PEPCK (Ma et al 2006), and increases hepatic glycogen synthesis, all potentially mediated through enhanced insulin sensitivity.
Positive_regulation (activation) of PEPCK
6) Confidence 0.08 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.23 Pain Relevance 0.27

General Comments

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