INT229289

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.32
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP7A1) extracellular region (FGF19) endoplasmic reticulum (CYP7A1)
Anatomy Link Frequency
bile 1
FGF19 (Homo sapiens)
CYP7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 39 96.56 Very High Very High Very High
Cholecystokinin 1 35.48 Quite Low
agonist 2 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Sumatriptan 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 6 91.84 High High
Diabetes Mellitus 29 89.68 High High
Body Weight 1 86.08 High High
Coronary Artery Disease 25 50.00 Quite Low
Atherosclerosis 13 50.00 Quite Low
Disorder Of Lipid Metabolism 23 5.00 Very Low Very Low Very Low
Hyperlipidemia 5 5.00 Very Low Very Low Very Low
Obesity 3 5.00 Very Low Very Low Very Low
Gallstones 3 5.00 Very Low Very Low Very Low
Hyperglycemia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FGF19 normally suppresses CYP7A1 (Holt et al 2003), possibly as a feedback response to increased cellular exposure to bile acids.
FGF19 Spec (possibly) Negative_regulation (suppresses) of CYP7A1 in bile associated with bile
1) Confidence 0.26 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.32 Pain Relevance 0.16

General Comments

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