INT229293

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.59
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (FXR1, NR0B2) cytoplasm (FXR1, NR0B2) nucleoplasm (NR0B2)
cell differentiation (FXR1) nucleolus (FXR1) RNA binding (FXR1)
FXR1 (Homo sapiens)
NR0B2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 39 89.36 High High
agonist 2 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Inflammatory marker 1 5.00 Very Low Very Low Very Low
Cholecystokinin 1 5.00 Very Low Very Low Very Low
Sumatriptan 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metabolic Disorder 1 84.36 Quite High
Repression 6 79.36 Quite High
Obesity 3 79.28 Quite High
Insulin Resistance 1 69.44 Quite High
Diabetes Mellitus 29 68.60 Quite High
Impaired Glucose Tolerance 1 67.60 Quite High
Coronary Artery Disease 25 50.00 Quite Low
Atherosclerosis 13 50.00 Quite Low
Body Weight 1 17.64 Low Low
Disorder Of Lipid Metabolism 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FXR activation normally induces expression of small heterodimer partner (SHP), which in turn, inhibits LXR activity, as well as CYP7A1 (Brendel et al 2002).
Positive_regulation (activation) of FXR Positive_regulation (induces) of Gene_expression (expression) of small heterodimer partner
1) Confidence 0.02 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.59 Pain Relevance 0.04

General Comments

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