INT2293

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Context Info
Confidence 0.61
First Reported 1978
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.16
Pain Relevance 1.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TYR) cell proliferation (TYR) lysosome (TYR)
cytoplasm (TYR)
Anatomy Link Frequency
skin 1
TYR (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 16 98.04 Very High Very High Very High
opiate 2 86.12 High High
melanocortin 1 receptor 1 45.28 Quite Low
Disease Link Frequency Relevance Heat
Sprains And Strains 2 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found a statistically significant association of MATP-374L (darker skin) with higher TYR protein abundance that was not observed for any NCKX5-111 or OCA2 rs12913832 allele.
Localization (abundance) of TYR in skin
1) Confidence 0.61 Published 2009 Journal J. Invest. Dermatol. Section Abstract Doc Link 18650849 Disease Relevance 0.16 Pain Relevance 0
A dimer of D-Ala2-enkephalin was relatively stable at short periods but subject to a 30% hydrolysis (vs. 100% for FK 33-824) in terms of Tyr release at longer periods of incubation.
Localization (release) of Tyr associated with enkephalin
2) Confidence 0.20 Published 1978 Journal Brain Res. Bull. Section Abstract Doc Link 400927 Disease Relevance 0 Pain Relevance 0.54
The enkephalin analog FK 33-824 was more stable at short incubation periods (30 min) than Met-enkephalin but less stable than D-Ala2-enkephalinamide at longer periods (180 min) as shown by the complete release of N-terminal Tyr.
Localization (release) of Tyr associated with enkephalin
3) Confidence 0.20 Published 1978 Journal Brain Res. Bull. Section Abstract Doc Link 400927 Disease Relevance 0 Pain Relevance 0.52

General Comments

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