INT229317

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.88
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (SLC2A4) small molecule metabolic process (SLC2A4) plasma membrane (SLC2A4)
carbohydrate metabolic process (SLC2A4) transmembrane transport (SLC2A4) cytoplasm (SLC2A4)
Anatomy Link Frequency
adipocytes 2
muscle 1
SLC2A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 9 85.00 Quite High
Bile 39 71.64 Quite High
cytokine 10 63.72 Quite High
agonist 2 54.32 Quite High
tolerance 23 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
behavioral therapy 5 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 45 99.30 Very High Very High Very High
Hyperinsulinism 7 99.10 Very High Very High Very High
Hypertension 7 99.10 Very High Very High Very High
Obesity 655 98.24 Very High Very High Very High
Insulin Resistance 35 96.76 Very High Very High Very High
Diabetes Mellitus 248 96.72 Very High Very High Very High
Metabolic Syndrome 52 94.28 High High
Cardiovascular Disease 6 93.44 High High
Repression 6 91.44 High High
Weight Loss 16 85.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This observation can be explained by the fact that SLC2A4 expression is increased during a hyperinsulinemic clamp in healthy muscle but not in type 2 diabetic muscle [22].
Gene_expression (expression) of SLC2A4 in muscle associated with diabetes mellitus
1) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.49 Pain Relevance 0
An increase in the expression of proteins promoting efficient GLUT4 trafficking and fusion to the membrane (like VAMP2) could be a way to compensate for a decreased amount of GLUT4 protein.
Gene_expression (expression) of GLUT4
2) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719801 Disease Relevance 0.50 Pain Relevance 0
prevents increased GLUT4 expression and deoxyglucose uptake in RIP140 depleted adipocytes.
Gene_expression (expression) of GLUT4 in adipocytes associated with obesity
3) Confidence 0.42 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.68 Pain Relevance 0
An impact on GLUT1 expression could not be excluded but was marginal compared to the impact on GLUT4 expression.
Gene_expression (expression) of GLUT4
4) Confidence 0.42 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.70 Pain Relevance 0
RIP140 knock down increases glucose uptake and expression of UCP-1 and GLUT4
Gene_expression (expression) of GLUT4 associated with targeted disruption
5) Confidence 0.42 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.12 Pain Relevance 0
Moreover, RIP140 reduce basal glucose transport and expression of the genes GLUT4 and UCP-1.
Gene_expression (expression) of GLUT4
6) Confidence 0.42 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.04 Pain Relevance 0
Similarly, additional experiments are necessary to clarify whether GLUT4 is directly regulated by RIP140 and what other transcriptional regulators are involved, or if altered GLUT4 expression is mediated through changes in adipocyte metabolism.
Gene_expression (expression) of GLUT4 in adipocyte
7) Confidence 0.42 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.55 Pain Relevance 0
Increased insulin signaling activity, along with increases in GLUT-4 protein expression, may lead to increased GLUT-4 translocation thereby increasing glucose transport and reducing insulin-resistance.
Gene_expression (expression) of GLUT-4 protein associated with hyperinsulinism
8) Confidence 0.13 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3010636 Disease Relevance 0.39 Pain Relevance 0
Moreover, we have recently shown that maintenance of cellular mTOR function by anti-hypertensive drugs improves insulin signaling increasing GLUT 4 expression and prevents micro-vascular rarefaction in spontaneously hypertensive rats with insulin resistance.
Gene_expression (expression) of GLUT 4 associated with hypertension and insulin resistance
9) Confidence 0.11 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940873 Disease Relevance 0.94 Pain Relevance 0.14
Specifically, increased LXR activity downregulates 11 beta-hydroxysteroid dehydrogenase type 1 (Stulnig et al 2002), downregules PPAR gamma, coactivator-1 alpha, and gluconeogenic enzymes such as PEPCK and glucose-6-phosphatase (Cao et al 2003; Laffitte et al 2003) and increases expression of glucokinase and GLUT-4 (Laffitte et al 2003).
Gene_expression (expression) of GLUT-4
10) Confidence 0.10 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.48 Pain Relevance 0.06

General Comments

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