INT229324

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.48
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GCK) nucleoplasm (GCK) small molecule metabolic process (GCK)
carbohydrate metabolic process (GCK) kinase activity (GCK) transmembrane transport (GCK)
GCK (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 39 71.64 Quite High
agonist 2 53.44 Quite High
tolerance 2 27.04 Quite Low
nud 3 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 6 90.56 High High
Impaired Glucose Tolerance 1 83.12 Quite High
Insulin Resistance 1 82.16 Quite High
Hyperglycemia 7 71.92 Quite High
Coronary Artery Disease 25 50.00 Quite Low
Atherosclerosis 13 50.00 Quite Low
Disorder Of Lipid Metabolism 23 48.64 Quite Low
Metabolic Disorder 1 47.68 Quite Low
Obesity 3 42.60 Quite Low
Diabetes Mellitus 41 31.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
corresponding to the difference between the current performance for task gk and the performance corresponding to the last time gk was tried, at a time denoted tg ?
Gene_expression (tried) of gk
1) Confidence 0.35 Published 2007 Journal Frontiers in Neurorobotics Section Body Doc Link PMC2533589 Disease Relevance 0 Pain Relevance 0
In particular, cocultured NPI showed a statistically significant increase of the expression of PDX-1, Glucokinase (GK), and GLUT-2 as compared to controls (P < .050).

3.4.

Gene_expression (expression) of Glucokinase
2) Confidence 0.14 Published 2010 Journal Stem Cells International Section Body Doc Link PMC2956457 Disease Relevance 0 Pain Relevance 0
Specifically, increased LXR activity downregulates 11 beta-hydroxysteroid dehydrogenase type 1 (Stulnig et al 2002), downregules PPAR gamma, coactivator-1 alpha, and gluconeogenic enzymes such as PEPCK and glucose-6-phosphatase (Cao et al 2003; Laffitte et al 2003) and increases expression of glucokinase and GLUT-4 (Laffitte et al 2003).
Gene_expression (expression) of glucokinase
3) Confidence 0.08 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.48 Pain Relevance 0.06

General Comments

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