INT229326

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.03
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP7A1) endoplasmic reticulum (CYP7A1)
Anatomy Link Frequency
bile 2
CYP7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 86 99.24 Very High Very High Very High
agonist 17 91.24 High High
Cholecystokinin 2 86.20 High High
Inflammation 5 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
nud 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Inflammatory marker 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 12 100.00 Very High Very High Very High
Gallstones 7 97.30 Very High Very High Very High
Metabolic Disorder 5 80.60 Quite High
Obesity 9 75.52 Quite High
Van Bogaert's Disease 3 74.88 Quite High
Insulin Resistance 4 74.48 Quite High
Impaired Glucose Tolerance 6 72.64 Quite High
Diabetes Mellitus 63 64.84 Quite High
Gallbladder Disease 3 50.40 Quite High
Coronary Artery Disease 52 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
FXR activation normally induces expression of small heterodimer partner (SHP), which in turn, inhibits LXR activity, as well as CYP7A1 (Brendel et al 2002).
Negative_regulation (inhibits) of CYP7A1
1) Confidence 0.29 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.58 Pain Relevance 0.05
Bile acids are a natural ligand for FXR, and activation of FXR results in repression of CYP7A1, thereby reducing bile acid synthesis.
Negative_regulation (repression) of CYP7A1 in bile associated with bile and repression
2) Confidence 0.29 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291317 Disease Relevance 0.10 Pain Relevance 0.43
This could be a potential risk for gallstone formation, if in humans receiving treatment with fibrates, bile acid synthesis is decreased over a longer period of time by a hepatic decrease of CYP7A1 activity.
Negative_regulation (decrease) of CYP7A1 in bile associated with bile and gallstones
3) Confidence 0.23 Published 2010 Journal PPAR Research Section Body Doc Link PMC2933910 Disease Relevance 0.34 Pain Relevance 0.22

General Comments

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