INT229350

Context Info Confidence 0.29 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.90 Pain Relevance 0

Anatomy Link Frequency heart 2 Hdlcl1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 2 5.00 Analgesic 1 5.00 anesthesia 1 5.00 withdrawal 1 5.00 ischemia 1 5.00 alcohol 1 5.00 Bile 1 5.00 tolerance 1 5.00 Catecholamine 1 5.00

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 125 100.00 Coronary Heart Disease 8 100.00 Cardiovascular Disease 5 97.68 Stress 10 85.96 Atherosclerosis 16 82.28 Death 5 78.88 Diabetes Mellitus 25 57.36 Dyslipidemia / Combined Dyslipidemia 21 50.00 Congenital Anomalies 2 5.64 Increased Venous Pressure Under Development 22 5.00

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A pooled analysis of Framingham and three other major North American trials (the Lipid Research Clinics Prevalence Mortality Follow-up Study, the Coronary Primary Prevention Trial and the Multiple Risk Factor Intervention Trial) showed that for each decrease in HDL-cholesterol of 0.03 mmol/L (1 mg/dL), the risk of coronary heart disease increased by 2% in men and by 3% in women (Gordon et al 1989).

Positive_regulation (increased) of Negative_regulation (decrease) of HDL-cholesterol in heart associated with coronary heart disease and disorder of lipid metabolism

1) Confidence 0.29 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 1.08 Pain Relevance 0

By all accounts, this study observed coffee intake induced significant increase in MDA levels and significant decrease in HDL-cholesterol, and other studies reported that coffee intake increased tHcy.

Positive_regulation (induced) of Negative_regulation (decrease) of HDL-cholesterol associated with disorder of lipid metabolism

2) Confidence 0.01 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2933445 Disease Relevance 0.82 Pain Relevance 0

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