INT229350

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.90
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
heart 2
Hdlcl1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Catecholamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 125 100.00 Very High Very High Very High
Coronary Heart Disease 8 100.00 Very High Very High Very High
Cardiovascular Disease 5 97.68 Very High Very High Very High
Stress 10 85.96 High High
Atherosclerosis 16 82.28 Quite High
Death 5 78.88 Quite High
Diabetes Mellitus 25 57.36 Quite High
Dyslipidemia /

Combined Dyslipidemia

21 50.00 Quite Low
Congenital Anomalies 2 5.64 Low Low
Increased Venous Pressure Under Development 22 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A pooled analysis of Framingham and three other major North American trials (the Lipid Research Clinics Prevalence Mortality Follow-up Study, the Coronary Primary Prevention Trial and the Multiple Risk Factor Intervention Trial) showed that for each decrease in HDL-cholesterol of 0.03 mmol/L (1 mg/dL), the risk of coronary heart disease increased by 2% in men and by 3% in women (Gordon et al 1989).
Positive_regulation (increased) of Negative_regulation (decrease) of HDL-cholesterol in heart associated with coronary heart disease and disorder of lipid metabolism
1) Confidence 0.29 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 1.08 Pain Relevance 0
By all accounts, this study observed coffee intake induced significant increase in MDA levels and significant decrease in HDL-cholesterol, and other studies reported that coffee intake increased tHcy.
Positive_regulation (induced) of Negative_regulation (decrease) of HDL-cholesterol associated with disorder of lipid metabolism
2) Confidence 0.01 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2933445 Disease Relevance 0.82 Pain Relevance 0

General Comments

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