INT229363

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.90
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Agt, Agtr1a) endosome (Agtr1a) extracellular space (Agt)
extracellular region (Agt) Golgi apparatus (Agtr1a) plasma membrane (Agtr1a)
Anatomy Link Frequency
lung 2
Agt (Rattus norvegicus)
Agtr1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 6 94.08 High High
Catecholamine 2 85.08 High High
Bioavailability 2 79.12 Quite High
antagonist 15 50.56 Quite High
beta blocker 5 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cough 6 97.64 Very High Very High Very High
Increased Venous Pressure Under Development 8 93.28 High High
Left Ventricular Hypertrophy 8 81.20 Quite High
Myocardial Infarction 48 74.36 Quite High
Natriuresis 3 68.12 Quite High
Hypertension 39 50.00 Quite Low
Left Ventricular Dysfunction 4 50.00 Quite Low
Diabetes Mellitus 11 5.00 Very Low Very Low Very Low
Renal Disease 11 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ARBs act by a different mechanism than ACE inhibitors by blocking the binding of angiotensin II to the AT1 receptor (Goodfriend et al 1996).
Negative_regulation (blocking) of angiotensin II Binding (binding) of AT1 receptor
1) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291334 Disease Relevance 0.90 Pain Relevance 0.26
It inhibits the binding of labeled angiotensin II to AT1 receptors in rat lung with a Ki of 3.7 nmol/L (Wienen et al 1993).
Negative_regulation (inhibits) of angiotensin II Binding (binding) of AT1 in lung
2) Confidence 0.22 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2293961 Disease Relevance 0 Pain Relevance 0.06

General Comments

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