INT22939

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Context Info
Confidence 0.78
First Reported 1984
Last Reported 2010
Negated 3
Speculated 2
Reported most in Abstract
Documents 164
Total Number 167
Disease Relevance 85.10
Pain Relevance 32.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Csf2) extracellular region (Csf2)
Anatomy Link Frequency
CSF 13
brain 9
granulocyte 6
macrophages 4
outflow 4
Csf2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 666 100.00 Very High Very High Very High
Nerve growth factor 401 100.00 Very High Very High Very High
cytokine 232 100.00 Very High Very High Very High
Dopamine 120 100.00 Very High Very High Very High
fibrosis 105 100.00 Very High Very High Very High
Analgesic 65 100.00 Very High Very High Very High
Congenital analgesia 2 100.00 Very High Very High Very High
Ziconotide 480 99.98 Very High Very High Very High
Paracetamol 166 99.98 Very High Very High Very High
Neuropathic pain 48 99.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 1597 100.00 Very High Very High Very High
INFLAMMATION 733 100.00 Very High Very High Very High
Mycobacterial Infection 194 100.00 Very High Very High Very High
Pressure And Volume Under Development 153 100.00 Very High Very High Very High
Fibrosis 132 100.00 Very High Very High Very High
Leukocytosis 8 100.00 Very High Very High Very High
Bacterial Respiratory Disease 4 100.00 Very High Very High Very High
Congenital Pain Insensitivity 2 100.00 Very High Very High Very High
Neuropathic Pain 189 99.98 Very High Very High Very High
Hemorrhagic Shock 42 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CSF from a patient with congenital indifference to pain was found to produce analgesia in the rat following intracerebroventricular injections.
Gene_expression (produce) of CSF in CSF associated with congenital analgesia, intracerebroventricular and analgesia
1) Confidence 0.78 Published 1984 Journal Experientia Section Abstract Doc Link 6210210 Disease Relevance 0.17 Pain Relevance 0.66
These results suggest that chronic neuropathic pain produces increased CSF levels of secretogogues for chromaffin cells, and illustrates the importance of host microenvironmental factors in determining graft function.
Gene_expression (produces) of CSF in CSF associated with neuropathic pain
2) Confidence 0.77 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10825645 Disease Relevance 0.57 Pain Relevance 0.71
These results indicate that G-CSF production specific for the hemorrhage component of shock is dependent on resuscitation.
Gene_expression (production) of G-CSF associated with shock and cva
3) Confidence 0.74 Published 1997 Journal Arch Orthop Trauma Surg Section Abstract Doc Link 9061173 Disease Relevance 1.03 Pain Relevance 0.28
The present study was designed to test the hypothesis that the upregulation of G-CSF mRNA expression is the consequence of HS followed by resuscitation and that ischemia alone is insufficient to induce G-CSF mRNA expression in the affected organs.
Gene_expression (expression) of G-CSF mRNA associated with ischemia and hemorrhagic shock
4) Confidence 0.74 Published 1997 Journal Arch Orthop Trauma Surg Section Abstract Doc Link 9061173 Disease Relevance 0.76 Pain Relevance 0.24
We have recently reported that in the lung and the liver of rats resuscitated after hemorrhagic shock (HS) G-CSF mRNA expression is induced.
Gene_expression (expression) of G-CSF mRNA in liver associated with hemorrhagic shock
5) Confidence 0.74 Published 1997 Journal Arch Orthop Trauma Surg Section Abstract Doc Link 9061173 Disease Relevance 0.65 Pain Relevance 0.22
Granulocyte colony-stimulating factor (G-CSF) production in hemorrhagic shock requires both the ischemic and resuscitation phase.
Gene_expression (production) of G-CSF in Granulocyte associated with hemorrhagic shock
6) Confidence 0.74 Published 1997 Journal Arch Orthop Trauma Surg Section Title Doc Link 9061173 Disease Relevance 0.68 Pain Relevance 0.22
The present study was designed to test the hypothesis that the upregulation of G-CSF mRNA expression is the consequence of HS followed by resuscitation and that ischemia alone is insufficient to induce G-CSF mRNA expression in the affected organs.
Gene_expression (expression) of G-CSF mRNA associated with ischemia and hemorrhagic shock
7) Confidence 0.74 Published 1997 Journal Arch Orthop Trauma Surg Section Abstract Doc Link 9061173 Disease Relevance 0.82 Pain Relevance 0.26
Since overproduction of CSF is relatively rare, most investigators have focused on CSF malabsorption as the most likely cause of hydrocephalus.
Gene_expression (overproduction) of CSF associated with hydrocephalus
8) Confidence 0.73 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0.50 Pain Relevance 0.03
Given that PGE2 levels in the CSF remain below this concentration in physiological as well as pathological conditions [21-23], neither the enzymatic nor the transport process will reach saturation.
Gene_expression (levels) of CSF
9) Confidence 0.72 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2292143 Disease Relevance 0 Pain Relevance 0
Moreover, ethanol fractions potently suppressed the expression of cycloxygenase (COX)-2 and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are stimulated by LPS in RAW264.7 cells.
Gene_expression (expression) of granulocyte-macrophage colony-stimulating factor in granulocyte
10) Confidence 0.71 Published 2008 Journal Phytother Res Section Abstract Doc Link 18688813 Disease Relevance 0.52 Pain Relevance 0.39
Moreover, ethanol fractions potently suppressed the expression of cycloxygenase (COX)-2 and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are stimulated by LPS in RAW264.7 cells.
Gene_expression (expression) of GM-CSF in granulocyte
11) Confidence 0.71 Published 2008 Journal Phytother Res Section Abstract Doc Link 18688813 Disease Relevance 0.52 Pain Relevance 0.39
The results of semi-quantitative RT-PCR demonstrated that PPF pretreatment significantly suppressed the LPS-induced toll-like receptor (TLR)-4, CD14, tumor necrosis factor (TNF)-alpha, and granulocyte-macrophage colony-stimulating factor (GM-CSF) gene expression.
Gene_expression (expression) of granulocyte-macrophage colony-stimulating factor in macrophage associated with necrosis and cancer
12) Confidence 0.70 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.37 Pain Relevance 0.19
The results of semi-quantitative RT-PCR demonstrated that PPF pretreatment significantly suppressed the LPS-induced toll-like receptor (TLR)-4, CD14, tumor necrosis factor (TNF)-alpha, and granulocyte-macrophage colony-stimulating factor (GM-CSF) gene expression.
Gene_expression (expression) of GM-CSF in macrophage associated with necrosis and cancer
13) Confidence 0.70 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.36 Pain Relevance 0.19
Moreover, addition of PD98059, a MAPK kinase inhibitor, significantly suppressed the LPS-induced NF-kappaB nuclear translocation and GM-CSF production, suggesting that the PPF-attenuated GM-CSF production in hepatocytes may be attributed to its suppressive effect on MAPK/ERK signaling pathway.
Gene_expression (production) of GM-CSF in hepatocytes
14) Confidence 0.70 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.20 Pain Relevance 0.07
Propofol pretreatment attenuates LPS-induced granulocyte-macrophage colony-stimulating factor production in cultured hepatocytes by suppressing MAPK/ERK activity and NF-kappaB translocation.
Gene_expression (production) of granulocyte-macrophage colony-stimulating factor in hepatocytes associated with cytokine
15) Confidence 0.70 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Title Doc Link 18387647 Disease Relevance 0.28 Pain Relevance 0.31
Moreover, addition of PD98059, a MAPK kinase inhibitor, significantly suppressed the LPS-induced NF-kappaB nuclear translocation and GM-CSF production, suggesting that the PPF-attenuated GM-CSF production in hepatocytes may be attributed to its suppressive effect on MAPK/ERK signaling pathway.
Gene_expression (production) of GM-CSF in hepatocytes
16) Confidence 0.70 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18387647 Disease Relevance 0.26 Pain Relevance 0.12
This application scheme is similar to the one used in the previous recovery experiment, but has a longer duration and lower single doses of G-CSF.
Gene_expression (duration) of G-CSF
17) Confidence 0.67 Published 2006 Journal BMC Biol Section Body Doc Link PMC1633735 Disease Relevance 0.74 Pain Relevance 0.08
G-CSF improves functional outcome after cerebral ischemia
Gene_expression (improves) of G-CSF associated with cv general 4 under development and ischemia
18) Confidence 0.67 Published 2006 Journal BMC Biol Section Body Doc Link PMC1633735 Disease Relevance 0.64 Pain Relevance 0.13
The collected CSF was transferred to centrifuge tubes and processed in an identical manner to the cyst fluid.


Gene_expression (transferred) of CSF in tubes associated with cyst
19) Confidence 0.65 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2898803 Disease Relevance 0.67 Pain Relevance 0
Classically, hydrocephalus has been attributed to an imbalance between CSF production and absorption.
Gene_expression (production) of CSF associated with hydrocephalus
20) Confidence 0.63 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2831828 Disease Relevance 0.50 Pain Relevance 0.03

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