INT229394

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Context Info
Confidence 0.00
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 3.11
Pain Relevance 2.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (TPSD1) extracellular region (TPSD1) Golgi apparatus (F2RL1)
plasma membrane (F2RL1) signal transducer activity (F2RL1)
Anatomy Link Frequency
mast cell 3
TPSD1 (Homo sapiens)
F2RL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 336 98.92 Very High Very High Very High
Inflammation 140 98.52 Very High Very High Very High
agonist 6 97.76 Very High Very High Very High
substance P 48 97.64 Very High Very High Very High
Nerve growth factor 32 96.36 Very High Very High Very High
Pain 37 95.80 Very High Very High Very High
Neuropeptide 11 91.44 High High
cytokine 74 89.72 High High
Bile 7 71.84 Quite High
Peripheral nervous system 2 66.28 Quite High
Disease Link Frequency Relevance Heat
Coagulation Disorder 1 99.76 Very High Very High Very High
Endometriosis 448 98.92 Very High Very High Very High
INFLAMMATION 134 98.52 Very High Very High Very High
Pain 39 95.80 Very High Very High Very High
Colitis 3 93.68 High High
Inflammatory Bowel Disease 3 90.72 High High
Apoptosis 11 89.32 High High
Neurogenic Inflammation 4 88.12 High High
Gastroesophageal Reflux Disease 45 76.56 Quite High
Esophageal Disease 20 69.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Of the four family members, PAR1, PAR3, and PAR4 are primarily activated by thrombin while PAR2 is activated by trypsin, mast cell tryptase, and clotting factors VIIa and Xa.
tryptase Positive_regulation (activated) of PAR2 in mast cell associated with coagulation disorder
1) Confidence 0.00 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291500 Disease Relevance 0.82 Pain Relevance 0.08
Activated mast cells release enzymes, such as tryptase, which stimulate protease-activated receptor (PAR)-2.
tryptase Positive_regulation (stimulate) of protease-activated receptor in mast cells
2) Confidence 0.00 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.76 Pain Relevance 0.33
Interestingly, the activation of PAR-2 on afferent neurons, e.g., by proteases such as mast cell tryptase, leads to subsequent release of pro-inflammatory CGRP and SP [169], which might provide explanation for pain during inflammation.
tryptase Positive_regulation (activation) of PAR-2 in mast cell associated with pain, inflammation and substance p
3) Confidence 0.00 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 1.53 Pain Relevance 1.73

General Comments

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