INT2294

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Context Info
Confidence 1.00
First Reported 1978
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 19
Total Number 19
Disease Relevance 0.64
Pain Relevance 10.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PENK) extracellular region (PENK)
Anatomy Link Frequency
plasma 3
cleavage 2
spinal cord 1
cerebrospinal fluid 1
brain 1
PENK (Homo sapiens)
PENK - M5T (2)
Pain Link Frequency Relevance Heat
Enkephalin 155 100.00 Very High Very High Very High
Analgesic 4 99.36 Very High Very High Very High
narcan 2 99.22 Very High Very High Very High
Dynorphin 9 98.96 Very High Very High Very High
Spinal cord 3 98.08 Very High Very High Very High
Neuropeptide 239 97.96 Very High Very High Very High
substantia gelatinosa 1 88.92 High High
transdermal 3 80.80 Quite High
Central nervous system 5 56.28 Quite High
Intracerebroventricular 1 52.84 Quite High
Disease Link Frequency Relevance Heat
Pheochromocytoma 8 99.34 Very High Very High Very High
Pox Virus Infection 3 88.04 High High
Cadaver 1 72.20 Quite High
Disease 19 61.88 Quite High
Pain 10 5.00 Very Low Very Low Very Low
Stress 8 5.00 Very Low Very Low Very Low
Hypertension 4 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The degradation rates of (Leu)-enkephalin and (Leu)-enkephalin-Arg6 were compared and the latter was degraded at a 10-fold higher rate.
Protein_catabolism (degradation) of enkephalin associated with enkephalin
1) Confidence 1.00 Published 1985 Journal FEBS Lett. Section Abstract Doc Link 2998876 Disease Relevance 0 Pain Relevance 0.30
The degradation rates of (Leu)-enkephalin and (Leu)-enkephalin-Arg6 were compared and the latter was degraded at a 10-fold higher rate.
Protein_catabolism (degradation) of enkephalin associated with enkephalin
2) Confidence 1.00 Published 1985 Journal FEBS Lett. Section Abstract Doc Link 2998876 Disease Relevance 0 Pain Relevance 0.30
When analyzed by radiochromatography detector on HPLC, degradation of enkephalin during transport was observed, with several degradation peaks in the chromatogram.
Protein_catabolism (degradation) of enkephalin associated with enkephalin
3) Confidence 0.95 Published 1996 Journal J Pharm Sci Section Abstract Doc Link 8926583 Disease Relevance 0.07 Pain Relevance 0.60
Seven groups of enkephalin-degrading enzymes and three groups of inhibitors active on these enzymes were separated from human plasma.
Protein_catabolism (degrading) of enkephalin-degrading in plasma associated with enkephalin
4) Confidence 0.88 Published 1990 Journal Neurochem. Res. Section Abstract Doc Link 2183083 Disease Relevance 0 Pain Relevance 0.42
In vitro human plasma leucine(5)-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure.
Protein_catabolism (degradation) of enkephalin in plasma associated with enkephalin
5) Confidence 0.82 Published 2003 Journal Pharmacology Section Title Doc Link 12444298 Disease Relevance 0 Pain Relevance 0.47
Interindividual variability observed seems controlled by two main factors: the pattern of enkephalin-degrading enzymes and, more notably, the low molecular weight plasma inhibitors.
Protein_catabolism (degrading) of enkephalin-degrading in plasma associated with enkephalin
6) Confidence 0.81 Published 1997 Journal Peptides Section Abstract Doc Link 9213370 Disease Relevance 0 Pain Relevance 0.34
Neuropeptidomic analyses by nano-liquid chromatography tandem mass spectrometry (LC-MS/MS) of neuropeptide-containing secretory vesicles isolated from a human pheochromocytoma revealed new information of how proenkephalin is processed (Fig. 3) (18).
Protein_catabolism (processed) of proenkephalin in vesicles associated with neuropeptide and pheochromocytoma
7) Confidence 0.64 Published 2010 Journal AAPS J Section Body Doc Link PMC2976990 Disease Relevance 0.32 Pain Relevance 2.39
Radiolabeled proenkephalin added to cell cultures was also cleaved to products similarly sized to those found in medium extracts; radiolabeled proenkephalin incubated in the absence of cells was not cleaved.
Protein_catabolism (cleaved) of proenkephalin
8) Confidence 0.64 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1729392 Disease Relevance 0 Pain Relevance 0.15
Radioactively labeled proenkephalin prepared with this system was also cleaved; however, under identical conditions bovine proinsulin was not cleaved.
Protein_catabolism (cleaved) of proenkephalin
9) Confidence 0.64 Published 1990 Journal Endocrinology Section Abstract Doc Link 2294000 Disease Relevance 0.09 Pain Relevance 0.19
The main dynorphin A peak at 5 kdalton was transferred to a major Leu-enkephalin-Arg6 peak by trypsin degradation.
Protein_catabolism (degradation) of enkephalin associated with dynorphin and enkephalin
10) Confidence 0.51 Published 1986 Journal Brain Res. Section Abstract Doc Link 2870778 Disease Relevance 0 Pain Relevance 0.87
Enkephalin degrading enzymes in cerebrospinal fluid.
Protein_catabolism (degrading) of Enkephalin in cerebrospinal fluid associated with enkephalin
11) Confidence 0.49 Published 1983 Journal Life Sci. Section Title Doc Link 6877031 Disease Relevance 0 Pain Relevance 0.54
AtT-20, was able to efficiently cleave pro-enkephalin to smaller peptides including Met-enkephalin.
Protein_catabolism (cleave) of pro-enkephalin in AtT-20 associated with enkephalin
12) Confidence 0.37 Published 1988 Journal Biochimie Section Abstract Doc Link 3135846 Disease Relevance 0.16 Pain Relevance 0.47
The results demonstrate the feasibility of altering the resistance of analogs of enkephalin and endorphin to degradation by brain enzymes.
Protein_catabolism (degradation) of enkephalin in brain associated with enkephalin
13) Confidence 0.37 Published 1978 Journal Brain Res. Bull. Section Abstract Doc Link 400927 Disease Relevance 0 Pain Relevance 0.46
The additional presence of D-Thr in position 6 of a triply substituted beta-endorphin (D-Thr6, D-Leu17, D-Lys29-beta-endorphin) did not affect liberation of Tyr, indicating that formation of gamma-endorphin (cleavage of Leu17-Phe) and of enkephalin (cleavage of Met5-Thr) need not occur before the action of brain peptidases.
Protein_catabolism (cleavage) of enkephalin (M5T) in cleavage associated with enkephalin
14) Confidence 0.33 Published 1978 Journal Brain Res. Bull. Section Abstract Doc Link 400927 Disease Relevance 0 Pain Relevance 0.52
The additional presence of D-Thr in position 6 of a triply substituted beta-endorphin (D-Thr6, D-Leu17, D-Lys29-beta-endorphin) did not affect liberation of Tyr, indicating that formation of gamma-endorphin (cleavage of Leu17-Phe) and of enkephalin (cleavage of Met5-Thr) need not occur before the action of brain peptidases.
Protein_catabolism (cleavage) of enkephalin (M5T) in cleavage associated with enkephalin
15) Confidence 0.33 Published 1978 Journal Brain Res. Bull. Section Abstract Doc Link 400927 Disease Relevance 0 Pain Relevance 0.58
Incubation with smaller lipotropic fragments (enkephalin, alpha-endorphin, gamma-endorphin) did not lead to further degradation.
Protein_catabolism (degradation) of enkephalin associated with enkephalin
16) Confidence 0.15 Published 1978 Journal Neurosci. Lett. Section Abstract Doc Link 19605248 Disease Relevance 0 Pain Relevance 0.10
Enkephalin-degrading enzymes and angiotensin-converting enzyme in human and rat meninges.
Protein_catabolism (degrading) of Enkephalin-degrading in meninges associated with enkephalin
17) Confidence 0.11 Published 1987 Journal FEBS Lett. Section Title Doc Link 3034668 Disease Relevance 0 Pain Relevance 0.51
To find a more effective inhibitor than spinorphin (LVVYPWT), an endogenous factor derived from bovine spinal cord, we synthesized spinorphin analogues and assayed their inhibitory activity toward DPPIII among enkephalin-degrading enzymes.
Protein_catabolism (degrading) of enkephalin-degrading in spinal cord associated with enkephalin and spinal cord
18) Confidence 0.02 Published 2000 Journal Peptides Section Abstract Doc Link 10822105 Disease Relevance 0 Pain Relevance 0.20
Angiotensin III: a potent inhibitor of enkephalin-degrading enzymes and an analgesic agent.
Protein_catabolism (degrading) of enkephalin-degrading associated with analgesic and enkephalin
19) Confidence 0.01 Published 1987 Journal J. Neurochem. Section Title Doc Link 3037031 Disease Relevance 0 Pain Relevance 0.80

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