INT229429

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Context Info
Confidence 0.65
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.80
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod1) aging (Sod1) peroxisome (Sod1)
intracellular (Sod1) protein complex (Sod1) cytoplasm (Sod1)
Anatomy Link Frequency
endothelial cells 1
smooth muscle 1
liver 1
Sod1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 20 90.04 High High
Bioavailability 8 69.96 Quite High
anesthesia 3 40.52 Quite Low
Bile 5 12.92 Low Low
Kinase C 2 6.76 Low Low
Inflammation 8 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 17 97.32 Very High Very High Very High
Injury 60 93.52 High High
Increased Venous Pressure Under Development 12 73.40 Quite High
Body Weight 40 62.20 Quite High
Insulin Resistance 6 56.72 Quite High
Stress 10 50.00 Quite Low
Obesity 18 44.88 Quite Low
Hyperinsulinism 6 28.00 Quite Low
Gallstones 13 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At least three isoforms of SOD exist in mammalian tissues, namely Cu/Zn SOD (SOD1), MnSOD (SOD2) and extracellular SOD (EcSOD or SOD3) that are located in cytosol, mitochondria and vascular smooth muscle, respectively [40,41].
Localization (located) of SOD1 in smooth muscle
1) Confidence 0.65 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0.07 Pain Relevance 0.12
In order to evaluate the contribution of Cu/Zn superoxide dismutase (SOD-1) in endothelial cells in response to exercise training, aortic and mesenteric expression of SOD-1 was determined by Western blotting assays.
Localization (contribution) of SOD-1 in endothelial cells
2) Confidence 0.65 Published 2008 Journal BMC Physiol Section Body Doc Link PMC2443377 Disease Relevance 0.06 Pain Relevance 0
We have shown that the activity of Cu,Zn-SOD, which is localized in the cytosol of cells, but not the activity of Mn-SOD, which is localized in the mitochondira of cells, in the liver of ANIT-treated rats decreases with liver injury development [8, 9].
Neg (not) Localization (localized) of Cu,Zn-SOD in liver associated with injury
3) Confidence 0.29 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291502 Disease Relevance 0.67 Pain Relevance 0

General Comments

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