INT22943

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Context Info
Confidence 0.47
First Reported 1990
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 16.09
Pain Relevance 5.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cytoplasm (Gpt)
Anatomy Link Frequency
plasma 6
blood 2
fat 2
liver 2
bile 2
Gpt (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 61 99.98 Very High Very High Very High
Osteoarthritis 3 99.06 Very High Very High Very High
pruritus 2 97.52 Very High Very High Very High
diclofenac 1 97.08 Very High Very High Very High
Bile 68 96.48 Very High Very High Very High
Pain 18 96.24 Very High Very High Very High
Inflammation 17 95.76 Very High Very High Very High
Arthritis 13 91.44 High High
fibrosis 5 90.32 High High
corticosteroid 4 86.12 High High
Disease Link Frequency Relevance Heat
Poisoning 18 100.00 Very High Very High Very High
Necrosis 16 100.00 Very High Very High Very High
Stress 20 99.88 Very High Very High Very High
Latent Tuberculosis 66 99.52 Very High Very High Very High
Hepatitis 35 99.48 Very High Very High Very High
Hepatitis C Virus Infection 8 99.38 Very High Very High Very High
Osteoarthritis 3 99.06 Very High Very High Very High
Injury 41 98.16 Very High Very High Very High
Pressure And Volume Under Development 19 98.04 Very High Very High Very High
Hepatotoxicity 64 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, when B6C3F1 mice were exposed to cold stress, the increase in plasma GPT activity induced by acetaminophen was significantly inhibited by 53% and 44%, respectively.
Positive_regulation (increase) of Positive_regulation (induced) of GPT in plasma associated with stress and paracetamol
1) Confidence 0.47 Published 1995 Journal Toxicol. Lett. Section Abstract Doc Link 8553366 Disease Relevance 0.49 Pain Relevance 0.51
However, when B6C3F1 mice were exposed to cold stress, the increase in plasma GPT activity induced by acetaminophen was significantly inhibited by 53% and 44%, respectively.
Positive_regulation (induced) of Positive_regulation (increase) of GPT in plasma associated with stress and paracetamol
2) Confidence 0.47 Published 1995 Journal Toxicol. Lett. Section Abstract Doc Link 8553366 Disease Relevance 0.49 Pain Relevance 0.51
BACKGROUND: In two recent osteoarthritis trials, alanine aminotransferase (ALT) elevations were observed more frequently in patients receiving acetaminophen 3.9 g daily than in patients receiving placebo, and the rates were higher than aminotransferase values observed in some previous osteoarthritis studies with acetaminophen.
Positive_regulation (observed) of Positive_regulation (elevations) of ALT associated with paracetamol and osteoarthritis
3) Confidence 0.44 Published 2006 Journal Curr Med Res Opin Section Abstract Doc Link 17076974 Disease Relevance 0.27 Pain Relevance 0.40
AAP (300 mg/kg) induced severe centrilobular necrosis and increased plasma alanine aminotransferase (ALT) activities (24 h: 3680 +/- 320 U/liter) in fasted C3Heb/FeJ mice.
Positive_regulation (induced) of Positive_regulation (increased) of ALT in plasma associated with necrosis and paracetamol
4) Confidence 0.43 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12954812 Disease Relevance 0.51 Pain Relevance 0.59
Diltiazem (24 mg/kg) reduced the increase in ALT induced by 1.1 mg/kg of phalloidine by 58% (4460 +/- 317 U/mL v.s. 1852 +/- 339 U/mL; p less than 0.05).
Positive_regulation (increase) of Positive_regulation (induced) of ALT
5) Confidence 0.41 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2353130 Disease Relevance 0.41 Pain Relevance 0.41
Diltiazem (24 mg/kg) reduced the increase in ALT induced by 1.1 mg/kg of phalloidine by 58% (4460 +/- 317 U/mL v.s. 1852 +/- 339 U/mL; p less than 0.05).
Positive_regulation (induced) of Positive_regulation (increase) of ALT
6) Confidence 0.41 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2353130 Disease Relevance 0.41 Pain Relevance 0.41
Pretreatment with AA (50 and 100mg/kg) orally 2h before the APAP administration attenuated the APAP-induced acute increase in serum aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activites, replenished the depleted hepatic glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities, decreased malondialdehyde (MDA) level and considerably reduced the histopathological alterations in a manner similar to silymarin (Sily).
Positive_regulation (induced) of Positive_regulation (increase) of ALT associated with paracetamol
7) Confidence 0.32 Published 2010 Journal Phytomedicine Section Abstract Doc Link 19836221 Disease Relevance 0.50 Pain Relevance 0.60
Pretreatment with AA (50 and 100mg/kg) orally 2h before the APAP administration attenuated the APAP-induced acute increase in serum aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activites, replenished the depleted hepatic glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) activities, decreased malondialdehyde (MDA) level and considerably reduced the histopathological alterations in a manner similar to silymarin (Sily).
Positive_regulation (activites) of Positive_regulation (increase) of ALT associated with paracetamol
8) Confidence 0.32 Published 2010 Journal Phytomedicine Section Abstract Doc Link 19836221 Disease Relevance 0.50 Pain Relevance 0.60
In high fat/cholesterol fed mice, the incidence and severity of elevated plasma ALT levels increased significantly as a function of the time the animals were maintained on this diet [22, 39].
Positive_regulation (increased) of Positive_regulation (elevated) of ALT in fat
9) Confidence 0.28 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 1.43 Pain Relevance 0
A considerable portion of amatoxin is taken up by hepatocytes, excreted into the bile and reabsorbed by the enterohepatic cycle.24,25 The amatoxins bind to RNA polymerase II and thus inhibit the hepatic formation of mRNA.26 As a result of this, Amanita species cause increases of AST(Aspartate aminotransferase) and ALT(Alanine aminotransferase) levels in the serum.27
Positive_regulation (cause) of Positive_regulation (increases) of ALT in bile associated with bile
10) Confidence 0.20 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2882543 Disease Relevance 0.43 Pain Relevance 0.05
The serum ALT elevation, with a peak at 24 h after Gal-N+LPS intoxication, was markedly augmented by means of the R1-mAb and R2-mAb.
Positive_regulation (augmented) of Positive_regulation (elevation) of serum ALT associated with poisoning
11) Confidence 0.15 Published 2010 Journal J Angiogenes Res Section Abstract Doc Link PMC2933582 Disease Relevance 0.51 Pain Relevance 0
During study period, eleven patients experienced elevated ALT levels over ten times the normal level, accompanied by high levels of serum bilirubin and thus were hospitalized.
Positive_regulation (experienced) of Positive_regulation (elevated) of ALT
12) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2430617 Disease Relevance 0.55 Pain Relevance 0.24
On acetaminophen-intoxicated model, the increased levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) by acetaminophen administration were reduced by treatment with these two herbs.
Positive_regulation (increased) of Positive_regulation (increased) of ALT associated with paracetamol
13) Confidence 0.06 Published 2000 Journal Am. J. Chin. Med. Section Abstract Doc Link 10794120 Disease Relevance 0.66 Pain Relevance 0.29
Five patients (14%, 5/36) receiving 3HR experienced transient elevation of AST or ALT during the LTBI treatment, which normalized spontaneously without discontinuing the treatment.
Positive_regulation (experienced) of Positive_regulation (elevation) of ALT associated with latent tuberculosis
14) Confidence 0.05 Published 2007 Journal Journal of Korean Medical Science Section Body Doc Link PMC2693840 Disease Relevance 0.91 Pain Relevance 0.04
Chitosan-DNA nanoparticles mediated only a moderate increase of both ALT and AST activities, slightly higher than that of naked DNA group.
Positive_regulation (mediated) of Positive_regulation (increase) of ALT
15) Confidence 0.04 Published 2006 Journal International Journal of Nanomedicine Section Body Doc Link PMC1828073 Disease Relevance 0.37 Pain Relevance 0.03
Although the simple ALT/LDH ratio seems to be acceptable in evaluation of the serum activity of LDH connecting to ALT, it could not reflect the degree of those enzymes' elevation from normal level when they are in relatively low levels because of the difference of their normal ranges.
Positive_regulation (acceptable) of Positive_regulation (simple) of ALT
16) Confidence 0.04 Published 2008 Journal Comp Hepatol Section Body Doc Link PMC2527551 Disease Relevance 0.18 Pain Relevance 0
Patients were excluded if they had functional class IV using SteinbrockerÂ’s criteria [10], aspartate transaminase (AST), alanine transaminase (ALT) and serum creatinine ?
Positive_regulation (using) of Positive_regulation (alanine) of ALT
17) Confidence 0.04 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2638601 Disease Relevance 1.10 Pain Relevance 0.37
Results of ALT and AST were minimally elevated in 1 and 4 patients respectively with the highest value being an ALT of 86 in patient #6 (data not shown in table) while LDH was elevated in 10 patients.
Positive_regulation (elevated) of Positive_regulation (Results) of ALT
18) Confidence 0.04 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC1885437 Disease Relevance 1.74 Pain Relevance 0.28
In this study, the injection of INH and RIF caused a significant elevation (approximately 2 fold increase) in the activities of ALT, AST and ALP.
Positive_regulation (caused) of Positive_regulation (elevation) of ALT
19) Confidence 0.03 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2491620 Disease Relevance 0.73 Pain Relevance 0
Clinically, several patients on chronic itraconazole therapy experienced elevated ALT and ALP activities [29].
Positive_regulation (experienced) of Positive_regulation (elevated) of ALT
20) Confidence 0.03 Published 2009 Journal Journal of Toxicology Section Body Doc Link PMC2809023 Disease Relevance 0.64 Pain Relevance 0.04

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