INT22944

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.26
First Reported 1985
Last Reported 2007
Negated 9
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 0.78
Pain Relevance 3.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Grhpr) cytoplasm (Grhpr)
Anatomy Link Frequency
plasma 1
colon 1
small intestines 1
Grhpr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 7 100.00 Very High Very High Very High
Inflammation 1 100.00 Very High Very High Very High
Paracetamol 14 99.10 Very High Very High Very High
qutenza 2 98.24 Very High Very High Very High
lidocaine 8 97.92 Very High Very High Very High
diclofenac 1 95.52 Very High Very High Very High
Morphine 2 92.04 High High
alcohol 6 89.28 High High
anesthesia 1 66.44 Quite High
anticonvulsant 1 50.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 3 100.00 Very High Very High Very High
Suicidal Behaviour 2 85.24 High High
Hepatotoxicity 3 75.00 Quite High
Ulcers 1 75.00 Quite High
Weight Gain 1 64.24 Quite High
Toxicity 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since these did not affect cytochrome C reductase activity, it was suggested that this inhibition of lidocaine metabolism in hepatic microsomes may have been caused by the reduction of activity on P-450 by the barbiturates.
Neg (not) Regulation (affect) of reductase associated with lidocaine
1) Confidence 0.26 Published 1998 Journal Masui Section Abstract Doc Link 9852692 Disease Relevance 0 Pain Relevance 0.44
We report here that ubiquinone analogues that contain a short, less hydrophobic side chain than coenzyme Q-10 dramatically stimulate the NADH-oxidase activity of isolated rat liver plasma membranes whereas they show no effect on the reductase activity of isolated membranes.
Neg (no) Regulation (effect) of reductase in plasma
2) Confidence 0.14 Published 1996 Journal J. Bioenerg. Biomembr. Section Abstract Doc Link 8953385 Disease Relevance 0 Pain Relevance 0.07
The aim of this study was to investigate the inhibitory effect of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors on the ulceration in small intestines of rats.
Spec (investigate) Regulation (effect) of reductase in small intestines
3) Confidence 0.06 Published 2005 Journal World J. Gastroenterol. Section Abstract Doc Link 15742411 Disease Relevance 0.24 Pain Relevance 0.28
The NADH:ferricyanide reductase, on the other hand, is particularly sensitive to pCMBS, indicating the presence of a sulfhydryl group of groups at its active site.
Regulation (sensitive) of reductase
4) Confidence 0.05 Published 1996 Journal J. Bioenerg. Biomembr. Section Abstract Doc Link 8953385 Disease Relevance 0 Pain Relevance 0.10
Similarly, hepatic microsomal NADPH-cytochrome c reductase, ethylmorphine N-demethylase and benzphetamine N-demethylase activities were also not affected by ethanol consumption.
Neg (not) Regulation (affected) of reductase
5) Confidence 0.03 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 3931644 Disease Relevance 0.13 Pain Relevance 0.25
The inhibition of cytochrome P-450-linked monooxygenase systems by FK-506 seemed to involve the direct inhibition of cytochromes P-450 because the NADPH-cytochrome c reductase and NADPH-ferricyanide reductase activities of NADPH-cytochrome P-450 reductase were not affected by the presence of 1 mM FK-506 at all.
Neg (not) Regulation (affected) of reductase
6) Confidence 0.03 Published 1997 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 9304807 Disease Relevance 0 Pain Relevance 0.08
The inhibition of cytochrome P-450-linked monooxygenase systems by FK-506 seemed to involve the direct inhibition of cytochromes P-450 because the NADPH-cytochrome c reductase and NADPH-ferricyanide reductase activities of NADPH-cytochrome P-450 reductase were not affected by the presence of 1 mM FK-506 at all.
Neg (not) Regulation (affected) of reductase
7) Confidence 0.03 Published 1997 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 9304807 Disease Relevance 0 Pain Relevance 0.08
The inhibition of cytochrome P-450-linked monooxygenase systems by FK-506 seemed to involve the direct inhibition of cytochromes P-450 because the NADPH-cytochrome c reductase and NADPH-ferricyanide reductase activities of NADPH-cytochrome P-450 reductase were not affected by the presence of 1 mM FK-506 at all.
Neg (not) Regulation (affected) of reductase
8) Confidence 0.03 Published 1997 Journal Int. J. Biochem. Cell Biol. Section Abstract Doc Link 9304807 Disease Relevance 0 Pain Relevance 0.08
Selenium pretreatment decreased the in vivo covalent binding of acetaminophen metabolites to hepatic protein, but did not alter hepatic microsomal cytochrome P-450 content or NADPH cytochrome c reductase activity, suggesting that selenium does not significantly alter the metabolism of acetaminophen to reactive electrophilic metabolites by the cytochrome P-450-dependent mixed-function oxidase enzyme system.
Neg (not) Regulation (alter) of reductase associated with paracetamol
9) Confidence 0.02 Published 1988 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 2901147 Disease Relevance 0.14 Pain Relevance 0.73
In rats, these changes were associated with a 30-fold elevation in the Vmax for microsomal ethoxyresorufin O-deethylase and a moderate increase in the Vmax for microsomal ethylmorphine N-demethylase, but no change in either the rate of aniline p-hydroxylation, 4-hydroxybiphenyl- or 4-methylumbelliferone UDP-glucuronosyltransferase, or the activity of the flavoprotein reductase component.
Neg (no) Regulation (change) of reductase
10) Confidence 0.02 Published 1987 Journal Drug Metab. Dispos. Section Abstract Doc Link 2888633 Disease Relevance 0 Pain Relevance 0.28
DDEP also produced a time-dependent decrease in total hepatic microsomal cytochrome P-450 but had no effect on either NADPH-cytochrome c reductase or p-nitrophenol glucuronyl-transferase activities up to 24 hr after administration.
Neg (no) Regulation (effect) of reductase
11) Confidence 0.02 Published 1986 Journal Mol. Pharmacol. Section Abstract Doc Link 3080674 Disease Relevance 0.16 Pain Relevance 0.09
As screened in a few groups, the changes in microsomal NADPH cytochrome c reductase were not noteworthy.
Regulation (changes) of reductase
12) Confidence 0.02 Published 1990 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 2353131 Disease Relevance 0 Pain Relevance 0.07
The in vivo effects of the non-steroid anti-inflammatory drug (NSAID) amtolmetin guacyl, a pro-drug of the NSAID tolmetin, on lipid peroxidation, glutathione levels and activity of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase) in rat gastric mucosa, colon mucosa and liver, were compared with the effects of non-selective (indomethacin, diclofenac) and COX-2 selective (celecoxib) NSAIDs. 2.
Regulation (effects) of reductase in colon associated with inflammation, cinod and diclofenac
13) Confidence 0.01 Published 2007 Journal Auton Autacoid Pharmacol Section Abstract Doc Link 17391279 Disease Relevance 0.10 Pain Relevance 0.47

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox