INT229457

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.98
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nefl) locomotion (Nefl)
Anatomy Link Frequency
neuronal 1
neurons 1
Nefl (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 57 92.64 High High
Sciatic nerve 93 53.28 Quite High
Spinal cord 30 40.16 Quite Low
butorphanol 3 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Dorsal column 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 63 99.84 Very High Very High Very High
Ganglion Cysts 66 92.64 High High
Schizophrenia 3 88.24 High High
Coronary Artery Disease 9 73.12 Quite High
Neuroblastoma 3 68.32 Quite High
Neurodegenerative Disease 3 42.44 Quite Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Embryonic Lethality 6 5.00 Very Low Very Low Very Low
Nervous System Injury 6 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mature CNS neurons, Ndel1 regulates Neurofilaments (NFs) assembly and homeostasis via a direct association with NF light chain (NF-L), thereby impacting neuronal survival [19].
NF-L Binding (association) of in neurons
1) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.30 Pain Relevance 0
Together, these results indicate that following injury, Ndel1 interacts differentialy with soluble neuronal Vimentin and NF-L in nervous tissues undergoing regeneration.


NF-L Binding (interacts) of in neuronal associated with injury
2) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.41 Pain Relevance 0.11
For instance, through association with Vimentin and NF-L, Ndel1 may favor the formation of NF/Vimentin heteropolymers in injured axons, thereby serving as an initial site for polymerization of Neurofilaments to rebuild the IF network and stabilize the growing axons.
NF-L Binding (association) of
3) Confidence 0.06 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.26 Pain Relevance 0.04

General Comments

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