INT229461

Context Info Confidence 0.53 First Reported 2008 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 5 Total Number 8 Disease Relevance 6.10 Pain Relevance 0.16

Anatomy Link Frequency blood vessel 3 Tsp1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 16 92.96 dorsal root ganglion 19 82.80 addiction 4 50.00 Sciatic nerve 31 5.00 imagery 20 5.00 Spinal cord 10 5.00 metalloproteinase 9 5.00 isoflurane 8 5.00 anesthesia 4 5.00 Paracetamol 4 5.00

Disease Link Frequency Relevance Heat Cancer 530 99.40 Breast Cancer 16 98.60 Prostate Cancer 75 97.80 Bladder Cancer 364 97.20 Injury 21 88.88 Ganglion Cysts 22 82.80 Recurrence 8 82.24 Malignant Neoplastic Disease 17 56.76 Targeted Disruption 63 50.00 Benign Prostatic Hypertrophy 4 48.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The data presented here are mainly correlative, and, certainly, more experimentation to examine the mechanisms involved in androgen regulation of TSP1 is required.

Spec (examine) Regulation (regulation) of TSP1

1) Confidence 0.53 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.10 Pain Relevance 0

Thus, the ADAMTS1-mediated effect on TSP1 levels could be a possible mechanism responsible for the switch in blood vessel morphology observed.

Regulation (effect) of TSP1 in blood vessel

2) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.69 Pain Relevance 0

This report is the first to show modulation of TSP1 by androgen manipulation in a non-hormonal cancer.

Regulation (modulation) of TSP1 associated with cancer

3) Confidence 0.23 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.69 Pain Relevance 0.07

This report is the first to show modulation of TSP1 by androgen manipulation in a non-hormonal cancer.

Regulation (modulation) of TSP1 associated with cancer

4) Confidence 0.23 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.74 Pain Relevance 0.05

This report presents data that support an androgen-regulated TSP1 hypothesis, which may be important in the angiogenic capabilities of BC.

Regulation (regulated) of TSP1 associated with bladder cancer

5) Confidence 0.23 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.83 Pain Relevance 0

The present study demonstrates that ADAMTS1 is an important regulatory factor of angiogenesis and tumor growth in prostate tumors, where modified ADAMTS1 expression resulted in markedly changed blood vessel morphology, possibly related to altered TSP1 levels.

Spec (possibly) Regulation (altered) of TSP1 in blood vessel associated with cancer and prostate cancer

6) Confidence 0.21 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2894797 Disease Relevance 0.80 Pain Relevance 0

In conclusion, modified ADAMTS1 expression resulted in markedly changed blood vessel morphology and altered TSP1 levels in the tumors.

Regulation (altered) of TSP1 in blood vessel associated with cancer

7) Confidence 0.21 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.02 Pain Relevance 0

By virtue of its association with molecular motors and its modulation of MTs and IFs [18], [19], [21], [22], [37]–[41], Ndel1 may remodel the cytoskeleton during axon regeneration.

Regulation (modulation) of MTs

8) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.23 Pain Relevance 0.04

General Comments

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