INT229461

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Context Info
Confidence 0.53
First Reported 2008
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 6.10
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood vessel 3
Tsp1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 16 92.96 High High
dorsal root ganglion 19 82.80 Quite High
addiction 4 50.00 Quite Low
Sciatic nerve 31 5.00 Very Low Very Low Very Low
imagery 20 5.00 Very Low Very Low Very Low
Spinal cord 10 5.00 Very Low Very Low Very Low
metalloproteinase 9 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Paracetamol 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 530 99.40 Very High Very High Very High
Breast Cancer 16 98.60 Very High Very High Very High
Prostate Cancer 75 97.80 Very High Very High Very High
Bladder Cancer 364 97.20 Very High Very High Very High
Injury 21 88.88 High High
Ganglion Cysts 22 82.80 Quite High
Recurrence 8 82.24 Quite High
Malignant Neoplastic Disease 17 56.76 Quite High
Targeted Disruption 63 50.00 Quite Low
Benign Prostatic Hypertrophy 4 48.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data presented here are mainly correlative, and, certainly, more experimentation to examine the mechanisms involved in androgen regulation of TSP1 is required.
Spec (examine) Regulation (regulation) of TSP1
1) Confidence 0.53 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 1.10 Pain Relevance 0
Thus, the ADAMTS1-mediated effect on TSP1 levels could be a possible mechanism responsible for the switch in blood vessel morphology observed.
Regulation (effect) of TSP1 in blood vessel
2) Confidence 0.34 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.69 Pain Relevance 0
This report is the first to show modulation of TSP1 by androgen manipulation in a non-hormonal cancer.


Regulation (modulation) of TSP1 associated with cancer
3) Confidence 0.23 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.69 Pain Relevance 0.07
This report is the first to show modulation of TSP1 by androgen manipulation in a non-hormonal cancer.


Regulation (modulation) of TSP1 associated with cancer
4) Confidence 0.23 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.74 Pain Relevance 0.05
This report presents data that support an androgen-regulated TSP1 hypothesis, which may be important in the angiogenic capabilities of BC.
Regulation (regulated) of TSP1 associated with bladder cancer
5) Confidence 0.23 Published 2008 Journal BMC Urol Section Body Doc Link PMC2374790 Disease Relevance 0.83 Pain Relevance 0
The present study demonstrates that ADAMTS1 is an important regulatory factor of angiogenesis and tumor growth in prostate tumors, where modified ADAMTS1 expression resulted in markedly changed blood vessel morphology, possibly related to altered TSP1 levels.



Spec (possibly) Regulation (altered) of TSP1 in blood vessel associated with cancer and prostate cancer
6) Confidence 0.21 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2894797 Disease Relevance 0.80 Pain Relevance 0
In conclusion, modified ADAMTS1 expression resulted in markedly changed blood vessel morphology and altered TSP1 levels in the tumors.
Regulation (altered) of TSP1 in blood vessel associated with cancer
7) Confidence 0.21 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.02 Pain Relevance 0
By virtue of its association with molecular motors and its modulation of MTs and IFs [18], [19], [21], [22], [37]–[41], Ndel1 may remodel the cytoskeleton during axon regeneration.
Regulation (modulation) of MTs
8) Confidence 0.02 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.23 Pain Relevance 0.04

General Comments

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