INT229467

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 18
Disease Relevance 2.71
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ndel1) transport (Ndel1) nuclear envelope (Ndel1)
chromosome segregation (Ndel1) chromosome (Ndel1) cytoskeleton (Ndel1)
Anatomy Link Frequency
neuronal 4
sciatic nerve 3
nerve 3
neurons 1
proximal 1
Ndel1 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 558 99.40 Very High Very High Very High
Spinal cord 180 95.84 Very High Very High Very High
dorsal root ganglion 342 91.48 High High
butorphanol 18 5.00 Very Low Very Low Very Low
Analgesic 18 5.00 Very Low Very Low Very Low
Dorsal column 18 5.00 Very Low Very Low Very Low
anesthesia 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 378 99.20 Very High Very High Very High
Embryonic Lethality 36 98.24 Very High Very High Very High
Ganglion Cysts 396 91.48 High High
Targeted Disruption 54 89.48 High High
Nervous System Injury 36 81.44 Quite High
Neuroblastoma 18 6.84 Low Low
Coronary Artery Disease 54 5.00 Very Low Very Low Very Low
Schizophrenia 18 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 18 5.00 Very Low Very Low Very Low
Infection 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, the results obtained with both sciatic nerve crush and transection models (Figs. 2 and 3) strongly indicated that formation of the neuronal Ndel1/Vimentin complex is linked to axonal regeneration.


Ndel1/Vimentin Binding (formation) of in neuronal associated with sciatic nerve
1) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.09 Pain Relevance 0.08
Together, these results indicated that formation of the neuronal Ndel1/Vimentin complex is associated with axonal nerve regeneration.


Ndel1/Vimentin Binding (formation) of in nerve
2) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.06 Pain Relevance 0.12
To seek further evidence for an in vivo association between Ndel1 and neuronal Vimentin in neurons, we isolated axoplasms and axonal preparations from sciatic nerve and spinal cord, respectively.
Ndel1 Binding (association) of in neurons associated with sciatic nerve and spinal cord
3) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.34 Pain Relevance 0.48
To determine whether the Ndel1/Vimentin complex forms in injured axons, we again took advantage of the neuronal expression pattern of Ndel1 and performed co-immunoprecipitations with Ndel1 antibodies on sciatic nerve soluble lysates.
Ndel1 Binding (immunoprecipitations) of in sciatic nerve associated with sciatic nerve
4) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.20 Pain Relevance 0.12
Ndel1 associates differentially with IFs following injury
Ndel1 Binding (associates) of associated with injury
5) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.10 Pain Relevance 0.07
Primers for Ndel1, Vimentin, GAP-43, and GAPDH, are: Ndel1 up 5?
Ndel1 Binding (Primers) of
6) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.06 Pain Relevance 0.07
Importantly, in the proximal segment of injured nerves where enhanced neuronal Ndel1/Vimentin association correlated with regeneration, there was reduced association between soluble Ndel1 and NF-L proteins when compared to the non-injured contralateral side (Fig. 4).
Ndel1/Vimentin Binding (association) of in nerves
7) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.25 Pain Relevance 0.06
The upregulation of soluble Ndel1 in injured nerves again led to enhanced formation of the neuronal Ndel1/full length Vimentin complex, as determined by co-immunoprecipitations with Ndel1 antibodies (Fig. 3B).
Ndel1 Binding (immunoprecipitations) of in neuronal
8) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0 Pain Relevance 0.13
By virtue of its association with molecular motors and its modulation of MTs and IFs [18], [19], [21], [22], [37]–[41], Ndel1 may remodel the cytoskeleton during axon regeneration.
Ndel1 Binding (association) of
9) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.24 Pain Relevance 0.04
As indicated by double labeling with a NF marker and confocal microscopy, both control and Ndel1 Alexa-conjugated siRNAs were incorporated in the proximal stump of nerve axons (Fig. 6B).
Ndel1 Binding (labeling) of in nerve
10) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.38 Pain Relevance 0.09
Upregulation of neuronal Ndel1/Vimentin complex correlates with regeneration after sciatic nerve transection
Ndel1/Vimentin Binding (complex) of in sciatic nerve associated with sciatic nerve
11) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.06 Pain Relevance 0.13
Importantly, in both proximal and distal segment of injured nerves, enhanced formation of neuronal Ndel1/Vimentin complex was observed after injury, as indicated by immunoprecipitations with Ndel1 antibodies (Fig. 2D).
Ndel1/Vimentin Binding (complex) of in distal segment associated with injury
12) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.18 Pain Relevance 0.03
A “residual” Ndel1/Vimentin complex in non-neuronal cells, if any, would have little effect on axon regeneration.


Ndel1/Vimentin Binding (complex) of in neuronal
13) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.16 Pain Relevance 0.05
Taken together, these results indicate that Ndel1 and Vimentin selectively co-associate in a subset of axons in vivo.
Ndel1 Binding (associate) of
14) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0 Pain Relevance 0.24
The upregulation of soluble Ndel1 in injured nerves again led to enhanced formation of the neuronal Ndel1/full length Vimentin complex, as determined by co-immunoprecipitations with Ndel1 antibodies (Fig. 3B).
Ndel1 Spec (determined) Binding (formation) of in neuronal
15) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0 Pain Relevance 0.13
Furthermore, using multiple biochemical and cellular methods, Ndel1 was found to associate with Vimentin in axons (Figs. 2 and 3).
Ndel1 Binding (associate) of
16) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.14 Pain Relevance 0.03
Mice lacking NF-L, another binding partner for Ndel1 differentially regulated during axon regeneration, exhibit delayed axon regeneration following sciatic nerve crush [32].
Ndel1 Binding (binding) of in sciatic nerve associated with sciatic nerve
17) Confidence 0.34 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.26 Pain Relevance 0.10
Importantly, in both proximal and distal segment of injured nerves, enhanced formation of neuronal Ndel1/Vimentin complex was observed after injury, as indicated by immunoprecipitations with Ndel1 antibodies (Fig. 2D).
Ndel1/Vimentin Binding (complex) of in proximal associated with injury
18) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.18 Pain Relevance 0.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox