INT229471

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Context Info
Confidence 0.28
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.86
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Vim) structural molecule activity (Vim) cytoskeleton (Vim)
cytoplasm (Vim)
Anatomy Link Frequency
radial 1
neurite 1
Vim (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 62 90.36 High High
Glutamate 10 76.44 Quite High
Central nervous system 13 59.20 Quite High
Spinal cord 20 45.68 Quite Low
Neuritis 1 25.20 Quite Low
dorsal root ganglion 39 5.00 Very Low Very Low Very Low
cerebral cortex 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Somatosensory cortex 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Coronary Artery Disease 6 98.48 Very High Very High Very High
Schizophrenia 3 95.20 Very High Very High Very High
Embryonic Lethality 4 94.88 High High
Targeted Disruption 6 92.68 High High
Neuroblastoma 2 92.16 High High
Death 13 74.92 Quite High
Nervous System Injury 4 69.84 Quite High
Injury 45 60.68 Quite High
Drug Induced Neurotoxicity 5 50.00 Quite Low
Rheumatoid Arthritis 7 43.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, we found that Nde1l forms a molecular complex with the IF Vimentin and regulates Vimentin dynamics during neurite extension in CAD cells [23].
Regulation (regulates) of Vimentin in neurite associated with coronary artery disease
1) Confidence 0.28 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.35 Pain Relevance 0.04
The essential role of Ndel1 during development and regeneration would be consistent with its upstream regulation on both Vimentin and NFs.


Regulation (regulation) of Vimentin
2) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.33 Pain Relevance 0.09
Together, these results indicate that NRG1 via activation of erbB3/erbB4 receptors and Pi3K induces a realignment of vimentin+ radial glia (see also Figure 8).


Regulation (realignment) of vimentin in radial
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965671 Disease Relevance 0 Pain Relevance 0
When cultured in the presence of dbcAMP, cells were immunopositive for vimentin, GFAP, O4, and GalC.
Regulation (immunopositive) of vimentin
4) Confidence 0.09 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2826742 Disease Relevance 0.18 Pain Relevance 0.10

General Comments

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