INT229481

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.47
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.73
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ndel1) transport (Ndel1) nuclear envelope (Ndel1)
chromosome segregation (Ndel1) chromosome (Ndel1) cytoskeleton (Ndel1)
Anatomy Link Frequency
neuronal 2
sciatic nerve 2
nerves 2
Ndel1 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 93 97.60 Very High Very High Very High
dorsal root ganglion 57 90.48 High High
Spinal cord 30 11.20 Low Low
butorphanol 3 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Dorsal column 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 63 98.96 Very High Very High Very High
Ganglion Cysts 66 90.48 High High
Nervous System Injury 6 60.20 Quite High
Embryonic Lethality 6 43.20 Quite Low
Coronary Artery Disease 9 5.00 Very Low Very Low Very Low
Targeted Disruption 9 5.00 Very Low Very Low Very Low
Neuroblastoma 3 5.00 Very Low Very Low Very Low
Schizophrenia 3 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 3 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Local silencing of Ndel1 by siRNA in injured nerves reduces axon regeneration
Positive_regulation (silencing) of Gene_expression (silencing) of Ndel1 in nerves
1) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.51 Pain Relevance 0.26
The degree of augmentation in Ndel1 levels also correlated with higher levels of GAP-43, a neuronal marker for axonal regeneration, and with stabilization of NF-L, a marker for advanced regeneration and maturation (Fig. 2C).
Positive_regulation (augmentation) of Gene_expression (levels) of Ndel1 in neuronal
2) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.22 Pain Relevance 0.07
Similar to the crush model, we observed synthesis and upregulation of Ndel1 and full length Vimentin in both injured distal and proximal nerve stumps when compared to the non-injured contralateral sides (control) at 65 hours following sciatic nerve transection (Fig. 3A and B).
Positive_regulation (upregulation) of Gene_expression (synthesis) of Ndel1 in sciatic nerve associated with sciatic nerve
3) Confidence 0.47 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0 Pain Relevance 0.14

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox