INT229496

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 2.05
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ndel1, Gopc) cytoplasm (Ndel1, Gopc) cell differentiation (Ndel1)
nuclear envelope (Ndel1) chromosome segregation (Ndel1) Golgi apparatus (Gopc)
Anatomy Link Frequency
nerves 3
sciatic nerve 2
proximal 1
distal segment 1
Ndel1 (Mus musculus)
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 90 97.68 Very High Very High Very High
Sciatic nerve 279 96.64 Very High Very High Very High
dorsal root ganglion 171 82.16 Quite High
butorphanol 9 5.00 Very Low Very Low Very Low
Analgesic 9 5.00 Very Low Very Low Very Low
Dorsal column 9 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 189 100.00 Very High Very High Very High
Ganglion Cysts 198 82.16 Quite High
Embryonic Lethality 18 81.44 Quite High
Nervous System Injury 18 75.52 Quite High
Coronary Artery Disease 27 5.00 Very Low Very Low Very Low
Targeted Disruption 27 5.00 Very Low Very Low Very Low
Neuroblastoma 9 5.00 Very Low Very Low Very Low
Schizophrenia 9 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low
Infection 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, in the distal segment where little regeneration occurs, Ndel1 still associates with soluble NF-L proteins (Fig. 4).
Ndel1 Binding (associates) of Fig in distal segment
1) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.38 Pain Relevance 0.10
We found enhanced formation of the Ndel1/Vimentin complex in proximal segments of crushed nerves (Fig. 2E).
Ndel1/Vimentin Binding (formation) of Fig in nerves
2) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.13 Pain Relevance 0.06
Again, we found enhanced formation of the Ndel1/Vimentin complex in injured axons, especially in the proximal segment (Fig. 3C).
Ndel1/Vimentin Binding (formation) of Fig in proximal
3) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.07 Pain Relevance 0.14
We found that truncated forms of Vimentin, but not the full length, co-immunoprecipitated with Ndel1 at these early time points (Fig. 2B; Fig.
Ndel1 Binding (immunoprecipitated) of Fig
4) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.21 Pain Relevance 0.11
We found that truncated forms of Vimentin, but not the full length, co-immunoprecipitated with Ndel1 at these early time points (Fig. 2B; Fig.
Ndel1 Binding (immunoprecipitated) of Fig
5) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.21 Pain Relevance 0.11
Importantly, in the proximal segment of injured nerves where enhanced neuronal Ndel1/Vimentin association correlated with regeneration, there was reduced association between soluble Ndel1 and NF-L proteins when compared to the non-injured contralateral side (Fig. 4).
Ndel1 Binding (association) of Fig in nerves
6) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.35 Pain Relevance 0.09
Using the “T” chamber with the proximal stump connected to the distal stump [33], [34], we delivered the Alexa 488-conjugated Ndel1 siRNA to sectioned nerve via the injection port beginning at 2 hours after injury, with repeated injections 1, 3 and 5 days post injury (Fig. 6A).
Ndel1 siRNA Binding (conjugated) of Fig in nerve associated with injury
7) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.59 Pain Relevance 0.20
Based on the selective presence of Ndel1/Vimentin complex in axons and neurons (Fig. 2), we next determined whether the formation of the complex is enhanced following sciatic nerve crush and transection.


Ndel1/Vimentin Binding (complex) of Fig in sciatic nerve associated with sciatic nerve
8) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.06 Pain Relevance 0.27
Based on the selective presence of Ndel1/Vimentin complex in axons and neurons (Fig. 2), we next determined whether the formation of the complex is enhanced following sciatic nerve crush and transection.


Ndel1/Vimentin Binding (complex) of Fig in sciatic nerve associated with sciatic nerve
9) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.06 Pain Relevance 0.27

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