INT229501

Context Info Confidence 0.05 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.32 Pain Relevance 0.08

structural molecule activity (Nefl, Vim) cytosol (Vim) cytoskeleton (Vim) locomotion (Nefl) cytoplasm (Vim)

Anatomy Link Frequency neuronal 1 Nefl (Mus musculus) Vim (Mus musculus)

Pain Link Frequency Relevance Heat dorsal root ganglion 38 94.56 Sciatic nerve 62 75.04 Spinal cord 20 5.00 butorphanol 2 5.00 Analgesic 2 5.00 Dorsal column 2 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Ganglion Cysts 44 94.56 Injury 42 83.48 Coronary Artery Disease 6 5.00 Targeted Disruption 6 5.00 Embryonic Lethality 4 5.00 Nervous System Injury 4 5.00 Neuroblastoma 2 5.00 Schizophrenia 2 5.00 Neurodegenerative Disease 2 5.00 Infection 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In tissues with higher regenerative capacity, Ndel1 preferentially associates with the neuronal form of Vimentin in detriment of NF-L.

NF-L Binding (associates) of Vimentin in neuronal

1) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.24 Pain Relevance 0.05

Based on this knowledge, we reasoned that upon axotomy, Ndel1 will interact less with NF-L (in favor of Vimentin) in tissues with higher regenerative potential.

NF-L Binding (interact) of Vimentin

2) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.08 Pain Relevance 0.04

General Comments

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