INT229507

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Context Info
Confidence 0.09
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 2.01
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ndel1) transport (Ndel1) nuclear envelope (Ndel1)
chromosome segregation (Ndel1) chromosome (Ndel1) structural molecule activity (Nefl)
Anatomy Link Frequency
neuronal 2
neurons 1
nerves 1
distal segment 1
Nefl (Mus musculus)
Ndel1 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 133 95.40 Very High Very High Very High
Sciatic nerve 217 75.48 Quite High
Spinal cord 70 43.16 Quite Low
butorphanol 7 5.00 Very Low Very Low Very Low
Analgesic 7 5.00 Very Low Very Low Very Low
Dorsal column 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 147 99.96 Very High Very High Very High
Ganglion Cysts 154 95.40 Very High Very High Very High
Schizophrenia 7 88.24 High High
Coronary Artery Disease 21 73.12 Quite High
Neuroblastoma 7 68.32 Quite High
Neurodegenerative Disease 7 45.44 Quite Low
Targeted Disruption 21 5.00 Very Low Very Low Very Low
Embryonic Lethality 14 5.00 Very Low Very Low Very Low
Nervous System Injury 14 5.00 Very Low Very Low Very Low
Infection 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In tissues with higher regenerative capacity, Ndel1 preferentially associates with the neuronal form of Vimentin in detriment of NF-L.
NF-L Binding (associates) of Ndel1 in neuronal
1) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.24 Pain Relevance 0.05
For instance, through association with Vimentin and NF-L, Ndel1 may favor the formation of NF/Vimentin heteropolymers in injured axons, thereby serving as an initial site for polymerization of Neurofilaments to rebuild the IF network and stabilize the growing axons.
NF-L Binding (association) of Ndel1
2) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.27 Pain Relevance 0.04
Based on this knowledge, we reasoned that upon axotomy, Ndel1 will interact less with NF-L (in favor of Vimentin) in tissues with higher regenerative potential.
NF-L Binding (interact) of Ndel1
3) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.08 Pain Relevance 0.04
In contrast, in the distal segment where little regeneration occurs, Ndel1 still associates with soluble NF-L proteins (Fig. 4).
NF-L Binding (associates) of Ndel1 in distal segment
4) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.38 Pain Relevance 0.10
Together, these results indicate that following injury, Ndel1 interacts differentialy with soluble neuronal Vimentin and NF-L in nervous tissues undergoing regeneration.


NF-L Binding (interacts) of Ndel1 in neuronal associated with injury
5) Confidence 0.08 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.41 Pain Relevance 0.11
Importantly, in the proximal segment of injured nerves where enhanced neuronal Ndel1/Vimentin association correlated with regeneration, there was reduced association between soluble Ndel1 and NF-L proteins when compared to the non-injured contralateral side (Fig. 4).
NF-L Binding (association) of Ndel1 in nerves
6) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.33 Pain Relevance 0.09
In mature CNS neurons, Ndel1 regulates Neurofilaments (NFs) assembly and homeostasis via a direct association with NF light chain (NF-L), thereby impacting neuronal survival [19].
NF-L Binding (association) of Ndel1 in neurons
7) Confidence 0.07 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291557 Disease Relevance 0.31 Pain Relevance 0

General Comments

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