INT229516

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 0.95
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
spleen 2
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 2 74.44 Quite High
agonist 20 43.48 Quite Low
imagery 6 33.44 Quite Low
Clonidine 10 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Thalamus 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 17 95.76 Very High Very High Very High
Disease 86 90.64 High High
Sprains And Strains 67 79.24 Quite High
Infection 20 77.52 Quite High
Scrapie 34 74.24 Quite High
Hypertension 12 66.88 Quite High
Amnesia 2 40.76 Quite Low
Creutzfeldt Jakob Disease 34 5.00 Very Low Very Low Very Low
Prion Diseases 12 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This inconsistent inhibition of PrPres accumulation in the spleen was reminiscent of that observed previously with MS-8209, an amphotericin B derivative [29] and suggests that GA does not act through inhibition of PrPSc accumulation in spleen.
Negative_regulation (inhibition) of Positive_regulation (accumulation) of PrPSc in spleen
1) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291559 Disease Relevance 0.34 Pain Relevance 0
A 6-days treatment with either TA or hTA in the 0 to 20 ┬ÁM range of concentration did not prevent PrPSc accumulation in chronically-infected MovS6 cells as shown by Western blot analysis (Figure 2, panel a and Figure S2, panel b) suggesting that both molecules may be inactive against these mammalian prions in the tested range of concentration.
Negative_regulation (prevent) of Positive_regulation (accumulation) of PrPSc
2) Confidence 0.37 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291559 Disease Relevance 0.23 Pain Relevance 0
Indeed, when we blocked PrP exit from EEs the levels of PrPSc were drastically reduced and an accumulation of PrPC in EEs was observed (Figures 2A, 2C, 5A, 5B, S8B, S8C and S8D).
Negative_regulation (blocked) of Positive_regulation (accumulation) of PrPC
3) Confidence 0.37 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.08 Pain Relevance 0
In a dividing cell, the process of cell division artificially enhances the rate of clearance and prevents the accumulation of PrPSc.
Negative_regulation (prevents) of Positive_regulation (accumulation) of PrPSc
4) Confidence 0.35 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2777304 Disease Relevance 0.06 Pain Relevance 0.04
Interestingly, the rate of spontaneous formation as well as the number of PMCA rounds needed to generate de novo PrPSc was different in distinct species.
Negative_regulation (number) of Positive_regulation (generate) of PrPSc
5) Confidence 0.24 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2675078 Disease Relevance 0.25 Pain Relevance 0

General Comments

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