INT229519

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.70
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Prnp) endoplasmic reticulum (Prnp) nucleolus (Prnp)
plasma membrane (Prnp) nucleus (Prnp) cytoplasm (Prnp)
Anatomy Link Frequency
brain 2
Prnp (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 4 63.12 Quite High
agonist 11 8.56 Low Low
imagery 12 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
Clonidine 5 5.00 Very Low Very Low Very Low
Thalamus 5 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 64 99.52 Very High Very High Very High
Scrapie 43 97.28 Very High Very High Very High
Infection 21 88.56 High High
Death 15 84.12 Quite High
Prion Diseases 35 50.00 Quite Low
Toxicity 5 34.20 Quite Low
Sprains And Strains 24 29.84 Quite Low
Creutzfeldt Jakob Disease 28 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 13 5.00 Very Low Very Low Very Low
Stress 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, we observed that Alix depletion did not affect the intracellular localization of PrPC and PrPSc, which were found to be enriched in the ERC similar to control cells (Figure 4B, compare colocalization with Tfn in control and treated cells for PrPC (?
Regulation (affect) of Localization (localization) of PrPC
1) Confidence 0.61 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.10 Pain Relevance 0
Interestingly, we observed that Alix depletion did not affect the intracellular localization of PrPC and PrPSc, which were found to be enriched in the ERC similar to control cells (Figure 4B, compare colocalization with Tfn in control and treated cells for PrPC (?
Regulation (affect) of Localization (localization) of PrPSc
2) Confidence 0.45 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.10 Pain Relevance 0
At terminal stage of the disease, GA has no significant effects on brain PrPSc accumulation as compared to solvent-treated mice (data not shown).
Neg (no) Regulation (effects) of Localization (accumulation) of PrPSc in brain associated with disease
3) Confidence 0.39 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291559 Disease Relevance 0.34 Pain Relevance 0
FK506 treatment does not alter PrPSc accumulation, but increases pCREB and pBAD
Neg (not) Regulation (alter) of Localization (accumulation) of PrPSc
4) Confidence 0.33 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2951383 Disease Relevance 0.16 Pain Relevance 0.03

General Comments

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