INT229557

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.83
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Ctla4) plasma membrane (Ctla4)
Anatomy Link Frequency
CD86 1
T cells 1
Ctla4 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 33 82.28 Quite High
Inflammation 26 68.16 Quite High
cytokine 34 56.80 Quite High
chemokine 14 5.00 Very Low Very Low Very Low
diabetic neuropathy 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
agonist 3 5.00 Very Low Very Low Very Low
member 8 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 308 99.22 Very High Very High Very High
Mycobacterial Infection 70 97.12 Very High Very High Very High
Infection 55 95.96 Very High Very High Very High
Autoimmune Disease 35 90.88 High High
Hypersensitivity 6 89.48 High High
Sprains And Strains 12 88.96 High High
Graft Vs Host Disease 10 87.36 High High
Glioma 9 84.40 Quite High
Brain Tumor 11 83.28 Quite High
Genetic Predisposition To Disease 8 78.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the mouse model of T1D, susceptibility was associated with a variation in ctla4 gene splicing with reduced production of a spliced form lacking the CD80/CD86 ligand-binding domain [2].
Positive_regulation (variation) of ctla4 in CD86 associated with diabetes mellitus
1) Confidence 0.43 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.42 Pain Relevance 0
Activation of Tregs stimulates the upregulation of CTLA4 on their cell surface and may thus be a useful target to specifically inhibit Tregs.
Positive_regulation (upregulation) of CTLA4
2) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.53 Pain Relevance 0.04
Although NOD alleles at MHC (Idd1) and Il2 (Idd3) are not sufficient for T1D in the NOD mouse [40], the NOD allele of Il2 may functionally differ from the B6 allele in its ability to direct the transcription of activation-induced CTLA-4 [5].
Positive_regulation (induced) of CTLA-4 associated with diabetes mellitus
3) Confidence 0.38 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685644 Disease Relevance 0.85 Pain Relevance 0
Subsequent adoptive transfer experiments, using naïve antigen-specific CD4+T cells, have revealed that in peptide tolerized WT animals there is an initial expansion of antigen-specific CD4+ T cells that have upregulated FoxP3, LAG3, CTLA4 and IFN-?
Positive_regulation (upregulated) of CTLA4 in T cells
4) Confidence 0.32 Published 2010 Journal European Journal of Immunology Section Body Doc Link PMC2988415 Disease Relevance 0.22 Pain Relevance 0.06
and Th17 (IL-23/IL-17) responses related to increased CTLA-4 and PD-1 expression (manuscript in press).
Positive_regulation (increased) of CTLA-4
5) Confidence 0.05 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710006 Disease Relevance 1.81 Pain Relevance 0.06

General Comments

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