INT229561

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 15
Disease Relevance 16.76
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Flt3l)
Anatomy Link Frequency
brain 3
T cells 3
dendritic cell 1
parenchyma 1
Flt3l (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 11 82.36 Quite High
tolerance 19 65.68 Quite High
agonist 22 63.52 Quite High
ischemia 11 58.16 Quite High
Arthritis 11 57.20 Quite High
Inflammation 114 48.40 Quite Low
cytokine 55 47.36 Quite Low
Bioavailability 11 36.12 Quite Low
headache 11 32.84 Quite Low
ketamine 26 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibromyalgia 45 100.00 Very High Very High Very High
Herpes Simplex Virus 19 100.00 Very High Very High Very High
Cancer 2891 99.92 Very High Very High Very High
Brain Tumor 561 99.16 Very High Very High Very High
Glioma 289 98.80 Very High Very High Very High
Death 89 98.72 Very High Very High Very High
Immunotherapy Of Cancer 48 94.64 High High
Glioblastoma 434 94.36 High High
Residual Neoplasm 12 94.00 High High
Disease 11 89.28 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our approach consists of expressing Fms-like tyrosine kinase 3 ligand (Flt3L), which induces DC infiltration into the brain parenchyma [7], in combination with the conditional cytotoxic gene thymidine kinase (TK) [8].
Gene_expression (expressing) of Flt3L in parenchyma associated with fibromyalgia
1) Confidence 0.65 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.33 Pain Relevance 0.03
Using a combined immunotherapy/conditional cytotoxic approach that utilizes adenoviral vectors (Ad) expressing Fms-like tyrosine kinase 3 ligand (Flt3L) and thymidine kinase (TK) delivered into the tumor mass, we demonstrated that CD4+ and CD8+ T cells were required for tumor regression and immunological memory.
Gene_expression (expressing) of Flt3L in T cells associated with cancer and fibromyalgia
2) Confidence 0.65 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.41 Pain Relevance 0.04
The researchers reveal that TLR2 was responding to high-mobility-group box 1 (HMGB1), a protein released by the dying tumor cells by showing that treatment of the tumor-bearing mice with the HMGB1 inhibitor glycyrrhizin blocked the therapeutic effect of Flt3L/TK expression.
Gene_expression (expression) of Flt3L associated with cancer
3) Confidence 0.65 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.28 Pain Relevance 0
This indicates that expression of Flt3L is necessary to induce the migration and differentiation of DCs within the tumor.
Gene_expression (expression) of Flt3L associated with cancer
4) Confidence 0.65 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.39 Pain Relevance 0.09
Expression of both Flt3L and TK (but not of either protein alone) plus gancyclovir treatment shrank the tumors and greatly improved the survival of the mice.
Gene_expression (Expression) of Flt3L associated with cancer
5) Confidence 0.65 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.20 Pain Relevance 0
By expressing Flt3L directly within the brain tumor we achieved infiltration of immune cells directly into the brain tumor microenvironment, and stimulation of a systemic antitumor immune response.
Gene_expression (expressing) of Flt3L in brain associated with brain tumor
6) Confidence 0.56 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 1.53 Pain Relevance 0.09
Finally, the researchers report that other tumor cell types release HMGB1 when they are killed and that the Flt3L/TK expression strategy can also kill other tumors growing in mouse brains.


Gene_expression (expression) of Flt3L in brains associated with cancer
7) Confidence 0.56 Published 2009 Journal PLoS Medicine Section Abstract Doc Link PMC2621261 Disease Relevance 1.23 Pain Relevance 0
We administered glycyrrhizin 2, 5, and 10 d after injection of Ad-Flt3L and Ad-TK or saline.
Gene_expression (injection) of Flt3L
8) Confidence 0.56 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.23 Pain Relevance 0
To uncover the role of TLR signaling in brain tumor regression and immunological memory, we developed a syngeneic, intracranial mouse glioma model; treatment consisted of intratumoral delivery of Ads expressing Flt3L and TK (Ad-TK + Ad-Flt3L), followed by systemic delivery of GCV.
Gene_expression (expressing) of Flt3L in brain associated with glioma and brain tumor
9) Confidence 0.50 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.56 Pain Relevance 0
We used first generation, recombinant Ads (serotype 5) expressing Herpes Simplex Virus Type I-TK (Ad-TK) [8,27], Flt3L (Ad-Flt3L) [7], and an Ad vector with no transgene (Ad0) in this study [8].
Gene_expression (generation) of Flt3L associated with herpes simplex virus
10) Confidence 0.50 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.85 Pain Relevance 0
We used first generation, recombinant Ads (serotype 5) expressing Herpes Simplex Virus Type I-TK (Ad-TK) [8,27], Flt3L (Ad-Flt3L) [7], and an Ad vector with no transgene (Ad0) in this study [8].
Gene_expression (generation) of Flt3L associated with herpes simplex virus
11) Confidence 0.50 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.85 Pain Relevance 0
We used first generation, recombinant adenoviral vectors (serotype 5) expressing Herpes Simplex Virus Type I Thymidine Kinase (Ad-TK) [27], [29] and Fms-like tyrosine kinase 3 ligand (Ad-Flt3L)[28], [49] in this study.
Gene_expression (expressing) of Flt3L associated with fibromyalgia and herpes simplex virus
12) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.53 Pain Relevance 0
Our approach consists of expressing Fms-like tyrosine kinase 3 ligand (Flt3L) which induces dendritic cell (DC) infiltration into the brain parenchyma [28] in combination with the conditional cytotoxic gene Thymidine Kinase (TK) [27], [29], which in the presence of GCV induces tumor cell death.
Gene_expression (expressing) of Flt3L in dendritic cell associated with cancer, fibromyalgia and death
13) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 1.70 Pain Relevance 0.03
Together, our data suggest that infiltration of mDC was an early event, probably induced by expression of Flt3L, whereas infiltration of T cells occurred later and was dependent on the successful initiation of adaptive immune responses against tumor antigens.
Gene_expression (expression) of Flt3L in T cells associated with cancer
14) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.73 Pain Relevance 0
In a T cell dependent model of brain tumor regression elicited by intratumoral delivery of adenoviral vectors (Ad) expressing Fms-like Tyrosine Kinase 3 ligand (Flt3L) and Herpes Simplex Type 1-Thymidine Kinase (TK) with ganciclovir (GCV), we demonstrate that administration of PC61 24 days after tumor implantation (7 days after treatment) inhibited T cell dependent tumor regression and long term survival.
Gene_expression (expressing) of Flt3L in T cell associated with cancer, herpes simplex virus, fibromyalgia and brain tumor
15) Confidence 0.42 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2291560 Disease Relevance 1.94 Pain Relevance 0

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